MARCHF5 and FIS1

Data Source:
HPRD (in vivo)

		MARCHF5	FIS1
Description		membrane associated ring-CH-type finger 5	fission, mitochondrial 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ATP Metabolic Process Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS			Rheumatoid arthritis ( 30891314)
Interacting Genes		39 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 MANBAL MAP1B MFN2 ODF4 PTPN5 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A	30 interacting genes: A2M ABHD6 APH1A BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1
Entrez ID		54708	51024
HPRD ID		07909	12352
Ensembl ID		ENSG00000198060	ENSG00000214253
Uniprot IDs		Q9NX47	Q9Y3D6
PDB IDs			1NZN 1PC2
Enriched GO Terms of Interacting Partners?
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