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MARCHF5 and MFN2
Data Source:
HPRD
(in vitro, in vivo)
MARCHF5
MFN2
Description
membrane associated ring-CH-type finger 5
mitofusin 2
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Integral Component Of Membrane
Intrinsic Component Of Mitochondrial Outer Membrane
Molecular Function
Protein Binding
Zinc Ion Binding
GTPase Binding
Ubiquitin Protein Ligase Activity
GTPase Activity
Protein Binding
GTP Binding
Ubiquitin Protein Ligase Binding
Biological Process
Protein Polyubiquitination
Protein Autoubiquitination
Protein Localization To Mitochondrion
Regulation Of Mitochondrial Fission
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Cell Aging
Protein Targeting To Mitochondrion
Apoptotic Process
Response To Unfolded Protein
Mitochondrial Membrane Organization
Cell Cycle Arrest
Blood Coagulation
Mitochondrial Fusion
Macroautophagy
Protein Localization To Phagophore Assembly Site
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Smooth Muscle Cell Proliferation
Mitochondrion Localization
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways
PINK1-PRKN Mediated Mitophagy
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Inflammatory skin disease (
25574825
)
Plasma homocysteine levels (
30339177
)
Platelet count (
22139419
32888494
)
Plateletcrit (
32888494
)
Tuberculosis (
29036319
)
Interacting Genes
39 interacting genes:
AKTIP
ANKS6
AQP6
BIK
BNIP1
CGRRF1
CREB3
ERGIC3
FATE1
FIS1
FUNDC1
GPX8
HSD17B13
MANBAL
MAP1B
MFN2
ODF4
PTPN5
RTN4IP1
SAR1A
SCD
SGPL1
SOD1
STMN4
TANK
TIMMDC1
TMEM139
TMEM14B
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E3
UBE2I
UBE2N
UBE2T
UBE2W
UTRN
YIF1A
2 interacting genes:
MARCHF5
PRKN
Entrez ID
54708
9927
HPRD ID
07909
08495
Ensembl ID
ENSG00000198060
ENSG00000116688
Uniprot IDs
Q9NX47
O95140
PDB IDs
6JFK
6JFL
6JFM
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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