PLD1 and ACTA1

Data Source:
HPRD (in vivo)

		PLD1	ACTA1
Description		phospholipase D1	actin alpha 1, skeletal muscle
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Neutrophil Degranulation Positive Regulation Of Translation Inositol Lipid-mediated Signaling Cell Motility Regulation Of Synaptic Vesicle Cycle	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation	Striated Muscle Contraction
Drugs		Choline LAX-101 Choline salicylate	Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321) Eosinophil counts ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		26 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		5337	58
HPRD ID		03855	00030
Ensembl ID		ENSG00000075651	ENSG00000143632
Uniprot IDs		Q13393 Q59EA4	P68133
PDB IDs		6U8Z
Enriched GO Terms of Interacting Partners?
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