PLD1 and PKN3

Data Source:
HPRD (in vivo, in vitro)

		PLD1	PKN3
Description		phospholipase D1	protein kinase N3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Nucleus Golgi Apparatus Perinuclear Region Of Cytoplasm
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Neutrophil Degranulation Positive Regulation Of Translation Inositol Lipid-mediated Signaling Cell Motility Regulation Of Synaptic Vesicle Cycle	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Intracellular Signal Transduction
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation	RHO GTPases activate PKNs
Drugs		Choline LAX-101 Choline salicylate
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321) Eosinophil counts ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494)	Apolipoprotein B levels ( 32203549) Asthma ( 31361310) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457) Gamma glutamyl transferase levels ( 29403010) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		26 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52
Entrez ID		5337	29941
HPRD ID		03855	17856
Ensembl ID		ENSG00000075651	ENSG00000160447
Uniprot IDs		Q13393 Q59EA4	A0A024R8D6 Q6P5Z2
PDB IDs		6U8Z
Enriched GO Terms of Interacting Partners?
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