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UCHL5 and PJA1
Data Source:
BioGRID
(enzymatic study)
UCHL5
PJA1
Description
ubiquitin C-terminal hydrolase L5
praja ring finger ubiquitin ligase 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Ino80 Complex
Cytoplasm
Molecular Function
RNA Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Cysteine-type Peptidase Activity
Proteasome Binding
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
DNA Repair
DNA Recombination
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Smoothened Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Pathways
Downregulation of TGF-beta receptor signaling
UCH proteinases
UCH proteinases
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Cannabis dependence (
21668797
)
Birth weight (
31043758
)
Body mass index (
29273807
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
102 interacting genes:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
ANXA8L1
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
E2F1
E2F2
E2F3
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
H4-16
H4C1
H4C11
H4C12
H4C13
H4C14
H4C15
H4C2
H4C3
H4C4
H4C5
H4C6
H4C8
H4C9
HAUS7
HBA1
HBA2
HBB
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
MAP3K1
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TCF7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBC
USP28
YWHAZ
ZBED1
64 interacting genes:
ABR
ASCC2
ATP5F1C
ATXN3
ATXN3L
CAMK1G
CDK16
COASY
CSAG3
DDX54
EED
ELAC1
ESPL1
EZH2
FGF12
GATD3A
GLO1
GSR
GTF2I
HNRNPC
HNRNPL
HOMER2
JOSD1
KIF22
LCP2
LRG1
MAGEB4
MAGED1
MDM2
METAP2
NAGK
NATD1
NDN
OTUB1
OTUB2
PCCA
PFKFB4
PHGDH
PIP4K2C
RIBC2
SPTBN1
STAC
STAM
STAMBP
SUZ12
TAF9
TK1
TMEM214
TSSK3
TXNDC5
UBE2D2
UBE2D3
UBE2E3
UBE2K
UBE2L3
UBE2U
UCHL3
UCHL5
USP20
USP28
USP5
USP51
USP8
ZNF440
Entrez ID
51377
64219
HPRD ID
10293
02335
Ensembl ID
ENSG00000116750
ENSG00000181191
Uniprot IDs
Q9Y5K5
Q8NG27
PDB IDs
3A7S
3IHR
3RII
3RIS
3TB3
4UEL
4UEM
4UF5
4UF6
4WLP
2L0B
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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