UCHL5 and KRT28

Data Source:
BioGRID (pull down)

		UCHL5	KRT28
Description		ubiquitin C-terminal hydrolase L5	keratin 28
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Peptidase Activity Proteasome Binding	Molecular_function Structural Molecule Activity Protein Binding
	Biological Process	DNA Repair DNA Recombination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process	Biological_process Keratinization Cornification
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Cannabis dependence ( 21668797)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Glucose homeostasis traits ( 25524916)
Interacting Genes		102 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	19 interacting genes: ABI3 CCDC196 DEUP1 KRT1 KRT3 KRT4 KRT5 KRT6A KRT6B KRT71 KRT79 KRT8 KRT80 KRT81 KRT86 NUP58 UCHL5 USHBP1 WASHC1
Entrez ID		51377	162605
HPRD ID		10293	17245
Ensembl ID		ENSG00000116750	ENSG00000173908
Uniprot IDs		Q9Y5K5	Q7Z3Y7
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?
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