PJA1 and UCHL3

Data Source:
BioGRID (enzymatic study)

		PJA1	UCHL3
Description		praja ring finger ubiquitin ligase 1	ubiquitin C-terminal hydrolase L3
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GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5
Entrez ID		64219	7347
HPRD ID		02335	04367
Ensembl ID		ENSG00000181191	ENSG00000118939
Uniprot IDs		Q8NG27	A0A087WTB8 A0A140VJZ4 P15374
PDB IDs		2L0B	1UCH 1XD3 6ISU 6QML
Enriched GO Terms of Interacting Partners?
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