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UCHL5 and ANXA1
Data Source:
BioGRID
(pull down)
UCHL5
ANXA1
Description
ubiquitin C-terminal hydrolase L5
annexin A1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Ino80 Complex
Cornified Envelope
Phagocytic Cup
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Extrinsic Component Of Membrane
Cytoplasmic Vesicle Membrane
Extrinsic Component Of External Side Of Plasma Membrane
Extrinsic Component Of Endosome Membrane
Motile Cilium
Early Endosome Membrane
Mitochondrial Membrane
Vesicle
Protein-containing Complex
Sarcolemma
Mast Cell Granule
Collagen-containing Extracellular Matrix
Extracellular Exosome
Synaptic Membrane
Molecular Function
RNA Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Cysteine-type Peptidase Activity
Proteasome Binding
Single-stranded DNA Binding
Single-stranded RNA Binding
Signaling Receptor Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipid Binding
Phospholipase A2 Inhibitor Activity
Double-stranded DNA Helicase Activity
Identical Protein Binding
Calcium-dependent Protein Binding
Cadherin Binding Involved In Cell-cell Adhesion
DNA/DNA Annealing Activity
Biological Process
DNA Repair
DNA Recombination
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Smoothened Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Neutrophil Homeostasis
Adaptive Immune Response
Monocyte Chemotaxis
Regulation Of Leukocyte Migration
Phagocytosis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Cell Shape
Response To X-ray
Myoblast Migration Involved In Skeletal Muscle Regeneration
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Insulin Secretion
Keratinocyte Differentiation
Prostate Gland Development
Endocrine Pancreas Development
Positive Regulation Of Vesicle Fusion
Positive Regulation Of Prostaglandin Biosynthetic Process
Actin Cytoskeleton Reorganization
Response To Estradiol
DNA Duplex Unwinding
Regulation Of Interleukin-1 Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Neutrophil Apoptotic Process
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Gliogenesis
Positive Regulation Of T Cell Proliferation
Response To Drug
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Estrous Cycle
Innate Immune Response
Positive Regulation Of T-helper 1 Cell Differentiation
Negative Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Exocytosis
Alpha-beta T Cell Differentiation
Regulation Of Hormone Secretion
Arachidonic Acid Secretion
Negative Regulation Of Protein Secretion
Regulation Of Inflammatory Response
Cellular Response To Hydrogen Peroxide
Hepatocyte Differentiation
Prolactin Secretion
Response To Interleukin-1
Cellular Response To Glucocorticoid Stimulus
Granulocyte Chemotaxis
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cell-cell Adhesion
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Phospholipase A2 Activity
Pathways
Downregulation of TGF-beta receptor signaling
UCH proteinases
UCH proteinases
G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Smooth Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
Drugs
Amcinonide
Fluocinolone acetonide
Hydrocortisone
Methylprednisolone
Clobetasol propionate
Budesonide
Dexamethasone
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Diseases
GWAS
Cannabis dependence (
21668797
)
Blood protein levels (
28240269
)
Chronotype (
30696823
)
Metabolite levels (
23823483
)
Parkinson's disease (
26227905
)
Schizophrenia, bipolar disorder and depression (combined) (
20713499
)
Urate levels in obese individuals (
25811787
)
Interacting Genes
102 interacting genes:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
ANXA8L1
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
E2F1
E2F2
E2F3
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
H4-16
H4C1
H4C11
H4C12
H4C13
H4C14
H4C15
H4C2
H4C3
H4C4
H4C5
H4C6
H4C8
H4C9
HAUS7
HBA1
HBA2
HBB
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
MAP3K1
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TCF7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBC
USP28
YWHAZ
ZBED1
34 interacting genes:
APBB1
CCT7
COPS6
CSAD
CZIB
DYSF
EGFR
ERG28
FAF1
FPR1
GAPDH
HMGA1
HSPB1
KLHL23
KMT2B
KRT8
LNPK
LRIF1
MEIS2
OTUB1
PRKCI
RPA1
S100A11
SRC
SUMO2
TGM2
TRPM7
UBE2D1
UBE2I
UBE3A
UCHL5
UNC119
USP7
YWHAQ
Entrez ID
51377
301
HPRD ID
10293
01060
Ensembl ID
ENSG00000116750
ENSG00000135046
Uniprot IDs
Q9Y5K5
P04083
Q5TZZ9
PDB IDs
3A7S
3IHR
3RII
3RIS
3TB3
4UEL
4UEM
4UF5
4UF6
4WLP
1AIN
1BO9
1QLS
5VFW
Enriched GO Terms of Interacting Partners
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