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PJA1 and UBE2K
Data Source:
BioGRID
(pull down)
PJA1
UBE2K
Description
praja ring finger ubiquitin ligase 1
ubiquitin conjugating enzyme E2 K
Image
GO Annotations
Cellular Component
Cytoplasm
Nucleus
Cytosol
Filopodium Tip
Molecular Function
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Ubiquitination
Protein Catabolic Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-threonine Phosphorylation
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K48-linked Ubiquitination
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Birth weight (
31043758
)
Body mass index (
29273807
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Schizophrenia (
25056061
29483656
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Plasma amyloid beta peptide concentrations (ABx-40) (
24535457
)
Platelet count (
32888494
)
Interacting Genes
64 interacting genes:
ABR
ASCC2
ATP5F1C
ATXN3
ATXN3L
CAMK1G
CDK16
COASY
CSAG3
DDX54
EED
ELAC1
ESPL1
EZH2
FGF12
GATD3A
GLO1
GSR
GTF2I
HNRNPC
HNRNPL
HOMER2
JOSD1
KIF22
LCP2
LRG1
MAGEB4
MAGED1
MDM2
METAP2
NAGK
NATD1
NDN
OTUB1
OTUB2
PCCA
PFKFB4
PHGDH
PIP4K2C
RIBC2
SPTBN1
STAC
STAM
STAMBP
SUZ12
TAF9
TK1
TMEM214
TSSK3
TXNDC5
UBE2D2
UBE2D3
UBE2E3
UBE2K
UBE2L3
UBE2U
UCHL3
UCHL5
USP20
USP28
USP5
USP51
USP8
ZNF440
95 interacting genes:
AMFR
ANAPC11
BARD1
BFAR
BIRC7
BIRC8
BRCA1
CASP12
CBLC
CCNC
CDC6
DDI1
DDX58
DIABLO
DTX3
DTX3L
DZIP3
EXOSC7
FZR1
HTT
ITCH
ITSN1
KRIT1
LRSAM1
MAP3K1
MARCHF3
MARCHF7
MDM2
MEOX2
MID1
MID2
MIPOL1
MKRN2
MKRN3
NEDD4L
NEDD8
NFKB1
NUB1
PAX6
PIAS4
PICK1
PJA1
PRKN
PRPF40A
PRRG4
RBCK1
RC3H2
REL
RING1
RLIM
RNF111
RNF114
RNF125
RNF138
RNF144A
RNF166
RNF167
RNF182
RNF183
RNF185
RNF2
RNF31
RNF32
RNF4
RNF41
RNF5
SDCBP
SENP1
SH3RF1
SIAH1
SMURF1
TP53
TRAF7
TRAIP
TRIM2
TRIM27
TRIM3
TRIM31
TRIM34
TRIM35
TRIM39
TRIM43
TRIM5
TRIM50
TRIM63
TSN
UBA1
UBB
UBE2I
UBOX5
UHRF2
USP1
WWP2
ZDHHC17
ZNF384
Entrez ID
64219
3093
HPRD ID
02335
04165
Ensembl ID
ENSG00000181191
ENSG00000078140
Uniprot IDs
Q8NG27
B3KSH4
B4DIZ2
P61086
PDB IDs
2L0B
1YLA
2O25
3E46
3F92
3K9O
3K9P
5DFL
6IF1
6JB6
6JB7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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