PJA1 and PCCA

Data Source:
BioGRID (enzymatic study)

		PJA1	PCCA
Description		praja ring finger ubiquitin ligase 1	propionyl-CoA carboxylase subunit alpha
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GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding CoA Carboxylase Activity Enzyme Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Biotin Metabolic Process Short-chain Fatty Acid Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism
Drugs			Biotin
Diseases			Propionic acidemia
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Corpus callosum anterior volume ( 31530798) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 23396134 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	4 interacting genes: ERRFI1 MCC PCCB PJA1
Entrez ID		64219	5095
HPRD ID		02335	01981
Ensembl ID		ENSG00000181191	ENSG00000175198
Uniprot IDs		Q8NG27	P05165
PDB IDs		2L0B	2CQY 2JKU
Enriched GO Terms of Interacting Partners?
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