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TMX2 and DERL1
Data Source:
BioGRID
(two hybrid)
TMX2
DERL1
Description
thioredoxin related transmembrane protein 2
derlin 1
Image
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Mitochondrial Membrane
Membrane-bounded Organelle
Mitochondria-associated Endoplasmic Reticulum Membrane
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
Protein Binding
Disulfide Oxidoreductase Activity
Identical Protein Binding
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Biological Process
Brain Development
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Pathways
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Neuroticism (
29255261
)
Problematic alcohol use (
32451486
)
Reticulocyte count (
32888494
)
Schizophrenia (
25056061
29483656
)
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
164 interacting genes:
AGPAT3
AGPAT4
AGPAT5
AIG1
AQP6
ARV1
ASGR1
ASPH
ATXN1
BDKRB1
BET1
BNIP1
BNIP2
BNIP3
BRICD5
BTN2A2
C2CD2L
C3orf52
CCDC167
CCL2
CD81
CDIPT
CDS2
CMTM7
COL8A2
COMMD8
COX20
CTSA
CTXN3
CXCL16
CXorf66
CYBC1
CYP4F2
DERL1
DGAT2L6
EMD
EMP3
F2RL1
FA2H
FAM177A1
FAM241B
FAM3C
FAXDC2
FDFT1
FUNDC2
FXYD6-FXYD2
GIMAP1
GIMAP5
GJB2
HACD2
HHATL
HMOX2
HSD17B11
HSD17B13
HSD3B7
HTATIP2
IER3
IER3IP1
IGFBP5
INSIG2
ITGAM
LEPROT
LEPROTL1
LHFPL5
LRAT
MALL
MFF
MFSD14B
MGLL
MGST3
MIP
MLN
MS4A1
MTNR1A
NAT8
NDUFA3
NINJ2
NRM
NSDHL
NSG1
ORMDL2
OTULINL
PAEP
PEDS1-UBE2V1
PEX16
PKMYT1
PLP2
PNLIPRP1
PRAF2
PRB1
PTAFR
PTPN9
RABAC1
REEP2
REEP4
RFT1
RNF24
RTP2
RUSF1
SACM1L
SCAMP5
SCD
SELENOK
SERF1A
SERF1B
SERP2
SFT2D1
SFXN1
SFXN3
SLC22A18
SLC22A2
SLC29A2
SLC35A1
SMAGP
SMCO4
SMIM1
STATH
STX12
STX3
STX7
THBD
THSD7B
TMBIM6
TMEM115
TMEM120A
TMEM120B
TMEM121
TMEM128
TMEM140
TMEM14B
TMEM14C
TMEM176A
TMEM201
TMEM203
TMEM208
TMEM222
TMEM239
TMEM254
TMEM31
TMEM50B
TMEM51
TMEM65
TMEM71
TMEM86B
TMEM97
TPRG1
TRAM1L1
TREX1
TSNARE1
TSPAN2
TVP23B
UBE2J1
UNC93A
VAMP1
VAMP3
VAMP4
VAMP5
VAPA
VAPB
WFDC2
YIF1A
YIPF1
YIPF2
YIPF6
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
Entrez ID
51075
79139
HPRD ID
07159
12302
Ensembl ID
ENSG00000213593
ENSG00000136986
Uniprot IDs
Q9Y320
A0A024R9G3
E5RGY0
Q9BUN8
PDB IDs
2DJ0
5GLF
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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