NFKBIA and CAPN1

Data Source:
HPRD (in vitro)

		NFKBIA	CAPN1
Description		NFKB inhibitor alpha	calpain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Protein Import Into Nucleus Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Protein Deubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Muramyl Dipeptide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Regulation Of Cell Population Proliferation Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of NIK/NF-kappaB Signaling	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Acetylsalicylic acid Bardoxolone methyl Astaxanthin	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases		Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Hodgkin lymphoma
GWAS		Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Creatine kinase levels ( 29403010) Eczema ( 31361310) Hip circumference adjusted for BMI ( 25673412) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) PR interval ( 32439900) Psoriasis ( 25854761 25903422 20953189 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878 28739976 30578418) White blood cell count ( 32888494)	Urate levels ( 31578528)
Interacting Genes		89 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 VCP ZNF212	54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		4792	823
HPRD ID		01235	00253
Ensembl ID		ENSG00000100906	ENSG00000014216
Uniprot IDs		P25963	B2RDI5 B4DWH5 P07384
PDB IDs		1IKN 1NFI 6TTU 6Y1J	1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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