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NFKBIA and UBE2D1
Data Source:
BioGRID
(enzymatic study)
NFKBIA
UBE2D1
Description
NFKB inhibitor alpha
ubiquitin conjugating enzyme E2 D1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
Protein Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Import Into Nucleus
Apoptotic Process
I-kappaB Kinase/NF-kappaB Signaling
Cytoplasmic Sequestering Of NF-kappaB
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Lipid Storage
Viral Process
Protein Deubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Muramyl Dipeptide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Negative Regulation Of DNA Binding
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Peroxisome
Protein Ubiquitination
Protein Deubiquitination
BMP Signaling Pathway
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Polyubiquitination
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
TICAM1, RIP1-mediated IKK complex recruitment
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
PR interval (
32439900
)
Psoriasis (
25854761
25903422
20953189
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
28739976
30578418
)
White blood cell count (
32888494
)
Brain imaging (
20100581
)
Crohn's disease (
21102463
)
Interacting Genes
89 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
VCP
ZNF212
239 interacting genes:
AMFR
ANAPC11
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIK
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
DDX58
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL17
FBXL2
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
H3C1
H4C1
HDAC6
HECW1
HERC2
HERC3
HERC5
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NONO
NQO1
NR1H2
OBI1
OTUB1
OTULIN
PELI1
PER2
PJA2
POLL
POLM
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5A
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF128
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF216
RNF25
RNF26
RNF31
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
RSAD2
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SMURF2
SPOP
STAM2
STUB1
SUFU
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TP53
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBTD1
UFM1
UHRF1
UHRF2
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
Entrez ID
4792
7321
HPRD ID
01235
04267
Ensembl ID
ENSG00000100906
ENSG00000072401
Uniprot IDs
P25963
A0A024QZJ2
A0A087WW00
P51668
PDB IDs
1IKN
1NFI
6TTU
6Y1J
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
Enriched GO Terms of Interacting Partners
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