CAPN1 and GPT

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CAPN1	GPT
Description		calpain 1	glutamic--pyruvic transaminase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Extracellular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity	L-alanine:2-oxoglutarate Aminotransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity	Cellular Amino Acid Biosynthetic Process Cellular Response To Insulin Stimulus Response To Starvation L-alanine Catabolic Process Positive Regulation Of Gluconeogenesis
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Alanine metabolism
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	Pyridoxal phosphate Glutamic acid Alanine Phenelzine
Diseases
GWAS		Urate levels ( 31578528)	Age at first birth ( 27798627) Alanine aminotransferase levels ( 30718733) Educational attainment ( 25201988) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273)
Interacting Genes		54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	2 interacting genes: CAPN1 CDC7
Entrez ID		823	2875
HPRD ID		00253	00689
Ensembl ID		ENSG00000014216	ENSG00000167701
Uniprot IDs		B2RDI5 B4DWH5 P07384	P24298
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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