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NFKBIA and TCL1A
Data Source:
BioGRID
(two hybrid)
NFKBIA
TCL1A
Description
NFKB inhibitor alpha
TCL1 family AKT coactivator A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Nucleoplasm
Endoplasmic Reticulum
Cytosol
Protein-containing Complex
Molecular Function
Protein Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Biological Process
Protein Import Into Nucleus
Apoptotic Process
I-kappaB Kinase/NF-kappaB Signaling
Cytoplasmic Sequestering Of NF-kappaB
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Lipid Storage
Viral Process
Protein Deubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Muramyl Dipeptide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Negative Regulation Of DNA Binding
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
PR interval (
32439900
)
Psoriasis (
25854761
25903422
20953189
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
28739976
30578418
)
White blood cell count (
32888494
)
Adverse response to aromatase inhibitors (
20876420
)
Mosaic loss of chromosome Y (
27064253
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Plateletcrit (
32888494
)
Refractive error (
32231278
)
Interacting Genes
89 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
VCP
ZNF212
38 interacting genes:
AKT1
AKT2
AKT3
ATM
CADPS
CALCOCO2
CARD9
CASP8AP2
CCDC13
CEP55
DDIT4L
DNMT3A
FLACC1
GOLGA2
H2AW
INCA1
LNX1
LNX2
LSM3
NFKBIA
NFKBID
NIF3L1
NTAQ1
PPP1R13B
PRTFDC1
REL
TAX1BP1
TCF4
TEPSIN
TNKS
TP53BP2
TRAF1
TRAF2
TRMT61A
TTC33
TXLNA
TXLNB
WDR47
Entrez ID
4792
8115
HPRD ID
01235
01744
Ensembl ID
ENSG00000100906
ENSG00000100721
Uniprot IDs
P25963
A0A024R6G5
P56279
PDB IDs
1IKN
1NFI
6TTU
6Y1J
1JSG
Enriched GO Terms of Interacting Partners
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