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NFKBIA and UBE2E3
Data Source:
HPRD
(in vitro, two hybrid)
NFKBIA
UBE2E3
Description
NFKB inhibitor alpha
ubiquitin conjugating enzyme E2 E3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Import Into Nucleus
Apoptotic Process
I-kappaB Kinase/NF-kappaB Signaling
Cytoplasmic Sequestering Of NF-kappaB
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Lipid Storage
Viral Process
Protein Deubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Muramyl Dipeptide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Negative Regulation Of DNA Binding
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Protein Polyubiquitination
Protein Ubiquitination
Regulation Of Growth
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
PR interval (
32439900
)
Psoriasis (
25854761
25903422
20953189
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
28739976
30578418
)
White blood cell count (
32888494
)
Ankylosing spondylitis (
23749187
)
Basophil count (
32888494
)
Body mass index (
25673413
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Heel bone mineral density (
30598549
)
Lymphocyte counts (
29403010
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Obesity (
21552555
)
QT interval (
29213071
)
Red blood cell count (
32888494
27863252
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Sweet taste preference (
32572145
)
White blood cell count (
27863252
)
Interacting Genes
89 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
VCP
ZNF212
95 interacting genes:
ACVR1
ARID3A
ARIH2
ARRDC3
ASXL2
ATXN1
BARD1
BRCA1
CADPS2
CBL
CHFR
CHUK
CNOT4
CUL1
CUL3
CUL4A
DAZAP2
DTX3
DTX3L
DZIP3
H3C1
H4C1
HERC4
HTT
IPO11
ITCH
KLHL42
MARCHF5
MDM2
MID1
MID2
MKRN3
MUL1
NEDD4L
NFKBIA
OTUB1
PGPEP1
PICK1
PJA1
PRKN
RANGAP1
RBX1
RC3H2
RCBTB1
RFWD3
RING1
RMND5B
RNF11
RNF111
RNF114
RNF115
RNF126
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF181
RNF185
RNF2
RNF25
RNF31
RNF4
RNF43
RNF5
RNF8
SAE1
SIAH1
SPOP
STUB1
TGFBR1
TRIM2
TRIM27
TRIM32
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TTC3
UBA1
UBC
UBOX5
UFM1
WBP2
WWP2
ZNF746
ZNRF1
ZNRF4
Entrez ID
4792
10477
HPRD ID
01235
05000
Ensembl ID
ENSG00000100906
ENSG00000170035
Uniprot IDs
P25963
Q969T4
R4GNG6
PDB IDs
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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