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CAPN1 and IL1A
Data Source:
HPRD
(in vitro)
CAPN1
IL1A
Description
calpain 1
interleukin 1 alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Extracellular Region
Extracellular Space
Cytosol
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Cytokine Activity
Interleukin-1 Receptor Binding
Copper Ion Binding
Protein Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Extracellular Matrix Disassembly
Receptor Catabolic Process
Neutrophil Degranulation
Regulation Of Catalytic Activity
Mammary Gland Involution
Cornification
Self Proteolysis
Regulation Of NMDA Receptor Activity
Fever Generation
Positive Regulation Of Cytokine Production
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Cellular Sodium Ion Homeostasis
Apoptotic Process
Inflammatory Response
Immune Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Immature T Cell Proliferation In Thymus
Cellular Response To Heat
Ectopic Germ Cell Programmed Cell Death
Positive Regulation Of Angiogenesis
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Response To Copper Ion
Positive Regulation Of Protein Secretion
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cell Division
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Rilonacept
Diseases
Graft-versus-host disease
GWAS
Urate levels (
31578528
)
Dysmenorrheic pain severity (
29855537
)
Endometriosis (
20844546
28537267
)
Gestational age at birth (child effect) (
31477735
)
Interleukin-1-receptor antagonist levels (
22205395
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Post-term birth (
31477735
)
Response to antipsychotic treatment in schizophrenia (working memory) (
21107309
)
Interacting Genes
54 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
11 interacting genes:
CAPN1
CASP1
HAX1
IL1R1
IL1R2
IL1RAP
KPNA6
MEOX2
NDN
NFKBIE
S100A13
Entrez ID
823
3552
HPRD ID
00253
00988
Ensembl ID
ENSG00000014216
ENSG00000115008
Uniprot IDs
B2RDI5
B4DWH5
P07384
P01583
PDB IDs
1ZCM
2ARY
1ITA
2ILA
2KKI
2L5X
5UC6
Enriched GO Terms of Interacting Partners
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