CAPN1 and NDUFB7

Data Source:
BioGRID (two hybrid)

		CAPN1	NDUFB7
Description		calpain 1	NADH:ubiquinone oxidoreductase subunit B7
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Respiratory electron transport Complex I biogenesis
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	NADH
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	41 interacting genes: AGBL2 ANKRD36B ATG9A C1orf109 CAPN1 CCDC24 CCNC CDCA7L CDKN2D CHIC2 CINP CKAP4 CTNNA3 ENKD1 FAM161B FAM90A1 GEM GPATCH2L GYS1 KRTAP10-10 LMO2 MAGOHB MAK MEIS2 MKRN3 MLKL NDUFB2 NFKBIB NFKBID RCOR3 RECK RIPPLY1 RIPPLY2 SCNM1 SPRED2 STRA6 TLE5 ZNF330 ZNF417 ZNF564 ZNF587
Entrez ID		823	4713
HPRD ID		00253	11957
Ensembl ID		ENSG00000014216	ENSG00000099795
Uniprot IDs		B2RDI5 B4DWH5 P07384	P17568
PDB IDs		1ZCM 2ARY	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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