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CAPN1 and ECHS1
Data Source:
BioGRID
(two hybrid, biochemical)
HPRD
(two hybrid)
CAPN1
ECHS1
Description
calpain 1
enoyl-CoA hydratase, short chain 1
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Mitochondrion
Mitochondrial Matrix
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Enoyl-CoA Hydratase Activity
Protein Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Extracellular Matrix Disassembly
Receptor Catabolic Process
Neutrophil Degranulation
Regulation Of Catalytic Activity
Mammary Gland Involution
Cornification
Self Proteolysis
Regulation Of NMDA Receptor Activity
Fatty Acid Beta-oxidation
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Branched-chain amino acid catabolism
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Hexanoyl-CoA
Octanoyl-Coenzyme A
Acetoacetyl-CoA
4-(N,N-Dimethylamino)cinnamoyl-CoA
Omega-3-carboxylic acids
Diseases
GWAS
Urate levels (
31578528
)
Lifespan (
25918517
)
Nonunion in individuals with fractures (
30680360
)
Interacting Genes
54 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
12 interacting genes:
CAPN1
CBWD2
CDC42
CLDN12
CYP2E1
ERCC6
GRB2
LRRK1
LRRK2
PPM1B
SERPINA1
UBA1
Entrez ID
823
1892
HPRD ID
00253
03799
Ensembl ID
ENSG00000014216
ENSG00000127884
Uniprot IDs
B2RDI5
B4DWH5
P07384
P30084
PDB IDs
1ZCM
2ARY
2HW5
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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