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NFKBIA and PTPN1
Data Source:
HPRD
(in vivo)
NFKBIA
PTPN1
Description
NFKB inhibitor alpha
protein tyrosine phosphatase non-receptor type 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Mitochondrial Matrix
Early Endosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Mitochondrial Crista
Protein-containing Complex
Sorting Endosome
Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
RNA Binding
Protein Tyrosine Phosphatase Activity
Insulin Receptor Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Cadherin Binding
Ephrin Receptor Binding
Protein Phosphatase 2A Binding
Biological Process
Protein Import Into Nucleus
Apoptotic Process
I-kappaB Kinase/NF-kappaB Signaling
Cytoplasmic Sequestering Of NF-kappaB
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Lipid Storage
Viral Process
Protein Deubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Muramyl Dipeptide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Negative Regulation Of DNA Binding
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Protein Dephosphorylation
Activation Of JUN Kinase Activity
Insulin Receptor Signaling Pathway
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Endocytosis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Actin Cytoskeleton Reorganization
Regulation Of Intracellular Protein Transport
Cellular Response To Unfolded Protein
Peptidyl-tyrosine Dephosphorylation
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
IRE1-mediated Unfolded Protein Response
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Positive Regulation Of Receptor Catabolic Process
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Integrin signaling
Negative regulation of MET activity
Regulation of IFNG signaling
PTK6 Down-Regulation
MECP2 regulates neuronal receptors and channels
Regulation of IFNA signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acid
5-(2-Fluoro-5-{(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]-1-propen-1-yl}phenyl)-1,2-oxazole-3-carboxylic acid
2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide
[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,
{4-[(2S)-2-({[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonic acid
Compound 19
3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acid
2-(Oxalyl-Amino)-Benzoic Acid
{[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)
Novo Nordisk a/S Compound
N-(Bromoacetyl)-beta-alanyl-N-(2-{4-[(carboxycarbonyl)amino]phenyl}ethyl)-L-serinamide
7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
PNU177836
2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
(4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acid
4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acid
L-cysteic acid
2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid
Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
2-[{4-[(2S)-2-{[(Allyloxy)carbonyl]amino}-3-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}amino)-3-oxopropyl]phenyl}(carboxycarbonyl)amino]benzoic acid
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide
[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
N-(3-Carboxypropanoyl)-L-phenylalanyl-3-carboxy-O-(carboxymethyl)-N-pentyl-L-tyrosinamide
1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID
ISIS 113715
Trodusquemine
Ertiprotafib
4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID
[(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid
4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID
2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
[(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid
5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID
ISOTHIAZOLIDINONE ANALOG
4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
p-Benzoyl-L-phenylalanine
6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
PR interval (
32439900
)
Psoriasis (
25854761
25903422
20953189
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
28739976
30578418
)
White blood cell count (
32888494
)
Basophil count (
32888494
)
Colorectal cancer (
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Intraocular pressure (
29617998
29785010
31959993
30054594
)
Lymphocyte percentage of white cells (
32888494
)
Thyroid stimulating hormone levels (
30843173
)
Vitiligo (
27723757
)
Interacting Genes
89 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
VCP
ZNF212
66 interacting genes:
ACTN1
AGR3
AKT1
AQP6
ASS1
BCAR1
BCAS3
BCR
CAPN2
CASC3
CASZ1
CAV1
CCL5
CDH13
CDH2
CDK1
CLK1
CLK2
COP1
CRK
CSNK2A1
CSNK2A2
CTNNB1
DIRAS3
EGFR
ELOVL4
ESR1
FGFR1
GHR
GLRX
GRB2
GSK3B
IGF1R
INSR
IRS1
JAK2
KLK7
LAT
LRATD2
LTK
MAPK1
MRC2
NFKBIA
NTRK1
NTRK2
NTRK3
PDGFRB
PIAS1
PIGP
PIN1
RHOBTB2
RRAS2
SNAI1
SRC
STAM2
STAT3
STAT5A
STAT5B
THRSP
TIMMDC1
TMEM31
TMEM41A
TMEM86B
TRPV6
TYK2
VPS45
Entrez ID
4792
5770
HPRD ID
01235
01477
Ensembl ID
ENSG00000100906
ENSG00000196396
Uniprot IDs
P25963
A8K3M3
B4DSN5
P18031
PDB IDs
1IKN
1NFI
6TTU
6Y1J
1A5Y
1AAX
1BZC
1BZH
1BZJ
1C83
1C84
1C85
1C86
1C87
1C88
1ECV
1EEN
1EEO
1G1F
1G1G
1G1H
1G7F
1G7G
1GFY
1I57
1JF7
1KAK
1KAV
1L8G
1LQF
1NL9
1NNY
1NO6
1NWE
1NWL
1NZ7
1OEM
1OEO
1OES
1OET
1OEU
1OEV
1ONY
1ONZ
1PA1
1PH0
1PTT
1PTU
1PTV
1PTY
1PXH
1PYN
1Q1M
1Q6J
1Q6M
1Q6N
1Q6P
1Q6S
1Q6T
1QXK
1SUG
1T48
1T49
1T4J
1WAX
1XBO
2AZR
2B07
2B4S
2BGD
2BGE
2CM2
2CM3
2CM7
2CM8
2CMA
2CMB
2CMC
2CNE
2CNF
2CNG
2CNH
2CNI
2F6F
2F6T
2F6V
2F6W
2F6Y
2F6Z
2F70
2F71
2FJM
2FJN
2H4G
2H4K
2HB1
2HNP
2HNQ
2NT7
2NTA
2QBP
2QBQ
2QBR
2QBS
2VEU
2VEV
2VEW
2VEX
2VEY
2ZMM
2ZN7
3A5J
3A5K
3CWE
3D9C
3EAX
3EB1
3EU0
3I7Z
3I80
3QKP
3QKQ
3SME
3ZMP
3ZMQ
3ZV2
4BJO
4I8N
4QAH
4QAP
4QBE
4QBW
4Y14
4ZRT
5K9V
5K9W
5KA0
5KA1
5KA2
5KA3
5KA4
5KA7
5KA8
5KA9
5KAA
5KAB
5KAC
5KAD
5QDE
5QDF
5QDG
5QDH
5QDI
5QDJ
5QDK
5QDL
5QDM
5QDN
5QDO
5QDP
5QDQ
5QDR
5QDS
5QDT
5QDU
5QDV
5QDW
5QDX
5QDY
5QDZ
5QE0
5QE1
5QE2
5QE3
5QE4
5QE5
5QE6
5QE7
5QE8
5QE9
5QEA
5QEB
5QEC
5QED
5QEE
5QEF
5QEG
5QEH
5QEI
5QEJ
5QEK
5QEL
5QEM
5QEN
5QEO
5QEP
5QEQ
5QER
5QES
5QET
5QEU
5QEV
5QEW
5QEX
5QEY
5QEZ
5QF0
5QF1
5QF2
5QF3
5QF4
5QF5
5QF6
5QF7
5QF8
5QF9
5QFA
5QFB
5QFC
5QFD
5QFE
5QFF
5QFG
5QFH
5QFI
5QFJ
5QFK
5QFL
5QFM
5QFN
5QFO
5QFP
5QFQ
5QFR
5QFS
5QFT
5QFU
5QFV
5QFW
5QFX
5QFY
5QFZ
5QG0
5QG1
5QG2
5QG3
5QG4
5QG5
5QG6
5QG7
5QG8
5QG9
5QGA
5QGB
5QGC
5QGD
5QGE
5QGF
5T19
6B8E
6B8T
6B8X
6B8Z
6B90
6B95
6BAI
6CWU
6CWV
6NTP
6OL4
6OLQ
6OLV
6OMY
6PFW
6PG0
6PGT
6PHA
6PHS
6PM8
Enriched GO Terms of Interacting Partners
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