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LATS1 and CDC26
Data Source:
BioGRID
(enzymatic study)
LATS1
CDC26
Description
large tumor suppressor kinase 1
cell division cycle 26
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Microtubule Organizing Center
Cytosol
Midbody
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Estrogen Receptor Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Sister Chromatid Segregation
Inner Cell Mass Cell Fate Commitment
Inner Cell Mass Cellular Morphogenesis
Protein Phosphorylation
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Keratinocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein Localization
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cytoplasmic Sequestering Of Protein
Cell Division
Mammary Gland Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Cell Division
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Signaling by Hippo
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Nicotine dependence and major depression (severity of comorbidity) (
30287806
)
Subcortical volume (MOSTest) (
32665545
)
Testicular germ cell tumor (
28604728
)
Interacting Genes
48 interacting genes:
ALPP
APP
ARPC3
AURKB
CAV1
CBY2
CDC26
CDK1
CEP76
EIF4EBP1
FOXL2
FSD2
GOLGA2
KRT31
LDOC1
LIMK1
LRRK2
MAGI3
MOAP1
MOB3A
MOB3B
MOB3C
MOB4
NEDD4
NF2
NUAK1
NUAK2
OSTF1
PABPN1
PPM1F
PPP1R11
PPP6R3
PTEN
RAC1
SMURF1
SMURF2
SSX2IP
STK3
STK4
TAZ
TFIP11
TRAF1
UBE2I
UBQLN2
WWOX
WWP1
WWTR1
ZYX
4 interacting genes:
ANAPC2
CDC16
CDC27
LATS1
Entrez ID
9113
246184
HPRD ID
09147
13012
Ensembl ID
ENSG00000131023
ENSG00000176386
Uniprot IDs
O95835
A0A024R832
Q8NHZ8
PDB IDs
4ZRK
5B5W
5BRK
3HYM
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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