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LATS1 and NUAK2
Data Source:
BioGRID
(enzymatic study)
LATS1
NUAK2
Description
large tumor suppressor kinase 1
NUAK family kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Microtubule Organizing Center
Cytosol
Midbody
Nucleus
Cytoplasm
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Estrogen Receptor Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Sister Chromatid Segregation
Inner Cell Mass Cell Fate Commitment
Inner Cell Mass Cellular Morphogenesis
Protein Phosphorylation
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Keratinocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein Localization
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cytoplasmic Sequestering Of Protein
Cell Division
Mammary Gland Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Phosphorylation
Apoptotic Process
Actin Cytoskeleton Organization
Intracellular Signal Transduction
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Pathways
Signaling by Hippo
Drugs
Fostamatinib
Fostamatinib
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Nicotine dependence and major depression (severity of comorbidity) (
30287806
)
Subcortical volume (MOSTest) (
32665545
)
Testicular germ cell tumor (
28604728
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
29403010
)
Meat-related diet (
32066663
)
Refractive error (
32231278
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
48 interacting genes:
ALPP
APP
ARPC3
AURKB
CAV1
CBY2
CDC26
CDK1
CEP76
EIF4EBP1
FOXL2
FSD2
GOLGA2
KRT31
LDOC1
LIMK1
LRRK2
MAGI3
MOAP1
MOB3A
MOB3B
MOB3C
MOB4
NEDD4
NF2
NUAK1
NUAK2
OSTF1
PABPN1
PPM1F
PPP1R11
PPP6R3
PTEN
RAC1
SMURF1
SMURF2
SSX2IP
STK3
STK4
TAZ
TFIP11
TRAF1
UBE2I
UBQLN2
WWOX
WWP1
WWTR1
ZYX
7 interacting genes:
ACVR1
APP
GRIPAP1
LATS1
SMAD2
SMAD4
TGFBR1
Entrez ID
9113
81788
HPRD ID
09147
12172
Ensembl ID
ENSG00000131023
ENSG00000163545
Uniprot IDs
O95835
B4E0Y5
Q9H093
PDB IDs
4ZRK
5B5W
5BRK
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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