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ARNT and FZR1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
ARNT
FZR1
Description
aryl hydrocarbon receptor nuclear translocator
fizzy and cell division cycle 20 related 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Aryl Hydrocarbon Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Membrane
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Aryl Hydrocarbon Receptor Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Protein Binding
Anaphase-promoting Complex Binding
Ubiquitin Ligase Activator Activity
Biological Process
Response To Hypoxia
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Transcription By RNA Polymerase II
Xenobiotic Metabolic Process
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Sumoylation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Positive Regulation Of Cell Population Proliferation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Meiotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Cell Division
Lens Fiber Cell Differentiation
Protein K11-linked Ubiquitination
Signal Transduction Involved In G2 DNA Damage Checkpoint
Negative Regulation Of Cell Aging
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Blood protein levels (
28240269
)
Body mass index (
26426971
)
Congenital left-sided heart lesions (
26965164
)
Cutaneous squamous cell carcinoma (
32041948
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Melanoma (
21983785
28212542
)
Metabolic syndrome (
31589552
)
Platelet count (
32888494
)
Rhegmatogenous retinal detachment (
23585552
)
Tea consumption (
31046077
)
Urate levels (
23263486
)
Red cell distribution width (
32888494
)
Interacting Genes
77 interacting genes:
ADH5
AHR
AHRR
AIP
AKT1
ARL14
ARNT2
BECN1
BRCA1
CALCOCO1
CASP3
CASP9
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CSNK2A1
DIABLO
EP300
EPAS1
EPHA2
ERBB2
ESR1
FGFR4
FZR1
GLIS1
GLIS2
GMNN
GTF2F1
GTF2F2
HEY1
HEY2
HGF
HIF1A
HIF3A
HNF4A
IRAK4
KPNA1
KPNA3
KPNA5
KPNA6
LATS2
LSM8
MAP2K5
MAPK14
MTA3
MYC
NCOA1
NCOA2
NCOA7
NCOR2
NF2
NPAS4
PDGFRA
PML
PTGES3
RAF1
RELA
SENP6
SIM1
SIM2
SMAD9
SP1
STK11
STRBP
TACC3
TEAD2
TGM2
TNFAIP1
TP53
TRIP11
TUBB2A
UBE2I
96 interacting genes:
AKT1
AKT1S1
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC5
ANAPC7
ARNT
AURKA
BECN1
BEX1
BLID
BTRC
BUB1B
C7orf25
CCL5
CCNB1
CCND2
CCNE1
CCNF
CDC14A
CDC20
CDC25A
CDC27
CDC6
CDK2
CDK4
CDK5
CDK6
CDKN2A
CDKN2B
CDR2
CDT1
CLSPN
CYP17A1
DCPS
DKK3
DNAJA1
DNM1L
E2F3
EPHA2
EPSTI1
ERBB2
FBXO5
FGFR4
GLIS2
GMNN
HECW2
HIF1A
KAT2A
KIF18B
LATS2
MAD2L2
MAK
MAP2K3
MAP2K5
MAP3K5
MAPK8
MET
MOAP1
MTA3
MYC
NAT2
NEDD9
NEK2
NF2
OTUD7B
PAX3
PCLAF
PDGFRA
PLK1
PSMC3IP
PTP4A3
PTTG1
RASSF1
RBBP8
SASS6
SENP2
SIRT2
SKIL
SKP2
SMURF1
SOX2
SOX4
SRC
STK11
TEAD2
TERT
THRSP
TP53
UBE2C
UBE2D1
UBE2D3
UBE2K
UBE2S
Entrez ID
405
51343
HPRD ID
00524
04687
Ensembl ID
ENSG00000143437
ENSG00000105325
Uniprot IDs
A8K6P0
B0AZM1
P27540
Q53F30
Q9UM11
PDB IDs
1D7G
1X0O
2A24
2ARN
2B02
2HV1
2K7S
3F1N
3F1O
3F1P
3H7W
3H82
4EQ1
4GHI
4GS9
4H6J
4LPZ
4PKY
4XT2
5TBM
5UFP
5V0L
6CZW
6D09
6D0B
6D0C
4UI9
5L9T
5L9U
Enriched GO Terms of Interacting Partners
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