MT-CO1 and HSPB2

Data Source:
BioGRID (two hybrid)

		MT-CO1	HSPB2
Description		cytochrome c oxidase subunit I	heat shock protein family B (small) member 2
Image
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex IV Integral Component Of Membrane Respiratory Chain Complex IV	Nucleus Cytoplasm Cytosol
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Heme Binding Metal Ion Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity
	Biological Process	Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Aging Aerobic Respiration Electron Transport Coupled Proton Transport Cerebellum Development Respiratory Electron Transport Chain Response To Copper Ion Response To Electrical Stimulus	Response To Unfolded Protein Regulation Of Catalytic Activity
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs		Cholic Acid N-Formylmethionine Oxygen
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Interacting Genes		10 interacting genes: CDC42 CLEC4G COX4I1 COX5A HSPB2 KCNMB1 LIG4 MEOX2 PRDX4 SNCA	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		4512	3316
HPRD ID		02469	03712
Ensembl ID		ENSG00000198804	ENSG00000170276
Uniprot IDs		A0A1X7RBG2 P00395 U5YWV7	A8KAH6 Q16082
PDB IDs		5Z62	6F2R
Enriched GO Terms of Interacting Partners?
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