HSPB2 and DDIT4

Data Source:
BioGRID (two hybrid)

		HSPB2	DDIT4
Description		heat shock protein family B (small) member 2	DNA damage inducible transcript 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity	Protein Binding 14-3-3 Protein Binding
	Biological Process	Response To Unfolded Protein Regulation Of Catalytic Activity	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction
Pathways			TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324) Refractive error ( 32231278)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	7 interacting genes: GSK3B HSPA4 HSPB2 LRIF1 LRRK2 PDPK1 TXNIP
Entrez ID		3316	54541
HPRD ID		03712	09662
Ensembl ID		ENSG00000170276	ENSG00000168209
Uniprot IDs		A8KAH6 Q16082	A0A024QZQ6 Q9NX09
PDB IDs		6F2R	3LQ9
Enriched GO Terms of Interacting Partners?
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