HSPB2 and MCCC2

Data Source:
BioGRID (two hybrid)

		HSPB2	MCCC2
Description		heat shock protein family B (small) member 2	methylcrotonoyl-CoA carboxylase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	3-methylcrotonyl-CoA Carboxylase Complex, Mitochondrial Mitochondrion Mitochondrial Matrix Cytosol Methylcrotonoyl-CoA Carboxylase Complex
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity	Methylcrotonoyl-CoA Carboxylase Activity Protein Binding ATP Binding
	Biological Process	Response To Unfolded Protein Regulation Of Catalytic Activity	Leucine Catabolic Process Biotin Metabolic Process Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Branched-chain amino acid catabolism
Drugs			Biotin
Diseases			3-Methylcrotonylglycinuria; 3-Methylcrotonyl-CoA carboxylase deficiency
GWAS			Chromosomal aberration frequency (chromatid type) ( 31586183) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Metabolite levels ( 23823483)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	1 interacting genes: HSPB2
Entrez ID		3316	64087
HPRD ID		03712	01952
Ensembl ID		ENSG00000170276	ENSG00000131844
Uniprot IDs		A8KAH6 Q16082	A0A140VK29 Q9HCC0
PDB IDs		6F2R
Enriched GO Terms of Interacting Partners?
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