HSPB2 and CYP1B1

Data Source:
BioGRID (two hybrid)

		HSPB2	CYP1B1
Description		heat shock protein family B (small) member 2	cytochrome P450 family 1 subfamily B member 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Response To Unfolded Protein Regulation Of Catalytic Activity	Angiogenesis Trabecular Meshwork Development Cellular Aromatic Compound Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Cell Adhesion Visual Perception Steroid Metabolic Process Estrogen Metabolic Process Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Toxin Metabolic Process Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Sterol Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Collagen Fibril Organization Negative Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Adhesion Mediated By Integrin Retinol Metabolic Process Retinal Metabolic Process Positive Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Membrane Lipid Catabolic Process Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Organic Cyclic Compound Endothelial Cell-cell Adhesion Omega-hydroxylase P450 Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Endogenous sterols Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective CYP1B1 causes Glaucoma
Drugs			Genistein 2-Methoxyestradiol Naringenin Quercetin beta-Naphthoflavone Flavone Cannabidiol Nabiximols
Diseases			Primary open angle glaucoma
GWAS			Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Basal cell carcinoma ( 31174203) Central corneal thickness ( 32528159) Cutaneous malignant melanoma ( 32341527 26237428) Frontal fibrosing alopecia ( 30850646) Keratinocyte cancer (MTAG) ( 31174203) Melanoma ( 28212542) Metabolite levels ( 23823483) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Parkinson's disease ( 26227905)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	1 interacting genes: HSPB2
Entrez ID		3316	1545
HPRD ID		03712	03464
Ensembl ID		ENSG00000170276	ENSG00000138061
Uniprot IDs		A8KAH6 Q16082	Q16678 Q53TK1
PDB IDs		6F2R	3PM0 6IQ5
Enriched GO Terms of Interacting Partners?
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