LORICRIN and KRT1

Data Source:
BioGRID (pull down)

		LORICRIN	KRT1
Description		loricrin cornified envelope precursor protein	keratin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Cornification	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Copper Zinc acetate
Diseases		Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS
Interacting Genes		7 interacting genes: CSTA EVPL IVL KRT1 PI3 SPRR3 VIM	51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ
Entrez ID		4014	3848
HPRD ID		01070	00763
Ensembl ID		ENSG00000203782	ENSG00000167768
Uniprot IDs		P23490	P04264
PDB IDs			4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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