KRT1 and TFIP11

Data Source:
BioGRID (two hybrid)

		KRT1	TFIP11
Description		keratin 1	tuftelin interacting protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Chromosome, Telomeric Region Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Nucleic Acid Binding Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Protein Binding Negative Regulation Of DNA Ligase Activity Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	mRNA Splicing - Major Pathway
Drugs		Zinc Copper Zinc acetate
Diseases		Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS
Interacting Genes		51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ	232 interacting genes: AARD ABI2 ABLIM3 AIMP2 ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAZ2B BCL6 BHLHA9 BMF BRD1 BYSL C1orf109 C2CD6 CARD9 CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCDC96 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CT55 CWF19L2 DAXX DDX25 DES DGCR6 DISC1 DPPA3 DTNB EAF2 EIF3A EIF3D ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNB2 LMO1 LMO2 LMO4 LSM3 LSP1P3 LYSMD1 MAB21L2 MCM7 MDM2 METTL17 MFAP1 MKRN3 MRPL11 MTFR2 MXD3 MYO15B MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRPF31 PSMA4 PSMC5 PSTPIP1 PTCD1 RCOR3 RHNO1 RIN1 RNF6 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SFR1 SGF29 SH2D4A SH3GLB1 SMARCB1 SMARCE1 SNAPIN SNRPB SNW1 SNX20 SNX32 SOGA1 SPG21 SSX2IP STRA8 STRN SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 USP2 USP6 USP7 VPS37C VPS39 WAC WASHC3 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12
Entrez ID		3848	24144
HPRD ID		00763	11628
Ensembl ID		ENSG00000167768	ENSG00000100109
Uniprot IDs		P04264	A0A024R1I7 Q9UBB9
PDB IDs		4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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