KRT1 and U2AF1L5

Data Source:
BioGRID (two hybrid)

		KRT1	U2AF1L5
Description		keratin 1	U2 small nuclear RNA auxiliary factor 1 like 5
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleoplasm Spliceosomal Complex Nuclear Speck U2AF Complex
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Protein Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification	MRNA Splicing, Via Spliceosome
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Zinc Copper Zinc acetate
Diseases		Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS
Interacting Genes		51 interacting genes: AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 PI3 PRKCE RINT1 SGTB TFIP11 TLCD4 TRIM54 U2AF1 U2AF1L5 UBE3A YWHAQ	15 interacting genes: AP1B1 AP2B1 CARNMT1 EFHC2 HNRNPK KRT1 KRT75 MEOX2 MLH1 SNRNP35 SRRM4 SRSF3 TRA2B U2AF2 ZNF417
Entrez ID		3848	102724594
HPRD ID		00763
Ensembl ID		ENSG00000167768	ENSG00000275895
Uniprot IDs		P04264	P0DN76 Q01081
PDB IDs		4ZRY 6E2J 6UUI	1JMT
Enriched GO Terms of Interacting Partners?
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