LORICRIN and PI3

		LORICRIN	PI3
Description		loricrin cornified envelope precursor protein	peptidase inhibitor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Extracellular Region Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Skin Epidermis
	Biological Process	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Cornification	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antimicrobial Humoral Response Antibacterial Humoral Response Innate Immune Response Cornification
Pathways		Formation of the cornified envelope	Antimicrobial peptides Formation of the cornified envelope
Drugs
Diseases		Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS			Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269) Malaria ( 31844061)
Interacting Genes		7 interacting genes: CSTA EVPL IVL KRT1 PI3 SPRR3 VIM	5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN
Entrez ID		4014	5266
HPRD ID		01070	15947
Ensembl ID		ENSG00000203782	ENSG00000124102
Uniprot IDs		P23490	P19957
PDB IDs			1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?
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