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KRT1 and KRT5
Data Source:
HPRD
(in vivo)
KRT1
KRT5
Description
keratin 1
keratin 5
Image
GO Annotations
Cellular Component
Cornified Envelope
Extracellular Region
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Membrane
Keratin Filament
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Nucleus
Cytoplasm
Cytosol
Intermediate Filament
Membrane
Keratin Filament
Extracellular Exosome
Molecular Function
Protein Binding
Carbohydrate Binding
Structural Constituent Of Skin Epidermis
Signaling Receptor Activity
Protein Heterodimerization Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Scaffold Protein Binding
Biological Process
Complement Activation, Lectin Pathway
Retina Homeostasis
Response To Oxidative Stress
Peptide Cross-linking
Keratinization
Fibrinolysis
Neutrophil Degranulation
Regulation Of Angiogenesis
Negative Regulation Of Inflammatory Response
Protein Heterotetramerization
Establishment Of Skin Barrier
Cornification
Cytoskeleton Organization
Epidermis Development
Keratinization
Hemidesmosome Assembly
Cornification
Pathways
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
Type I hemidesmosome assembly
Keratinization
Formation of the cornified envelope
Drugs
Zinc
Copper
Zinc acetate
Zinc
Zinc acetate
Diseases
Epidermolytic palmoplantar keratoderma (EPPK)
Ichthyosis hystrix, Curth-Macklin type
Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
Striate palmoplantar keratoderma
Dowling-Degos disease
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Basal cell carcinoma (
31174203
24403052
25855136
27539887
)
Cutaneous squamous cell carcinoma (
32041948
)
Keratinocyte cancer (MTAG) (
31174203
)
Non-melanoma skin cancer (
29739929
)
Squamous cell carcinoma (
31174203
)
Interacting Genes
51 interacting genes:
AMOTL2
CALB2
CSTA
DSP
EVPL
F12
FANCA
FANCC
FFAR2
GOLGA2
GOLGA6L9
HAUS1
HMG20A
HOOK2
IVL
KNG1
KRT13
KRT14
KRT15
KRT16
KRT19
KRT24
KRT25
KRT26
KRT27
KRT28
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT5
LINC00839
LORICRIN
MBL2
NINL
NUP62
PI3
PRKCE
RINT1
SGTB
TFIP11
TLCD4
TRIM54
U2AF1
U2AF1L5
UBE3A
YWHAQ
25 interacting genes:
ALOX12
ALOX12B
APC
DSP
DST
EVPL
INCA1
KIFC3
KRT1
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT27
KRT28
KRT31
KRT35
KRT38
KRT40
PKP2
TCHP
UBE3A
Entrez ID
3848
3852
HPRD ID
00763
01010
Ensembl ID
ENSG00000167768
ENSG00000186081
Uniprot IDs
P04264
P13647
PDB IDs
4ZRY
6E2J
6UUI
3TNU
6JFV
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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