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NOTCH2NLA and PRKAA2
Data Source:
BioGRID
(two hybrid)
NOTCH2NLA
PRKAA2
Description
notch 2 N-terminal like A
protein kinase AMP-activated catalytic subunit alpha 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Neuronal Cell Body
Molecular Function
Notch Binding
Calcium Ion Binding
Protein Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Notch Signaling Pathway
Cerebral Cortex Development
Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Response To Muscle Activity
Wnt Signaling Pathway
Macroautophagy
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Drug
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Regulation Of Stress Granule Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Prostaglandin E Stimulus
Energy Homeostasis
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Cellular Protein Localization
Negative Regulation Of Tubulin Deacetylation
Positive Regulation Of Peptidyl-lysine Acetylation
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Lymphocyte counts (
22286170
)
Interacting Genes
357 interacting genes:
ACY3
ADAM12
ADAMTSL3
ADAMTSL4
ADAMTSL5
ADCK5
AGXT
ALDH16A1
ALDH3B1
ALPI
ALPP
ANKS1A
AQP1
AQP5
ARID3A
ASPSCR1
ATG9A
ATP5F1D
BCAM
BCL6B
BLCAP
BMP7
BRME1
C11orf87
C5orf60
CA6
CARHSP1
CATSPER1
CCDC26
CCDC93
CCER1
CD164
CDK5R1
CELF5
CERK
CHCHD3
CHDH
CHIC2
CHRD
CHRNG
CLDN2
CLEC18A
CNNM3
COL8A1
CRACR2A
CRCT1
CREB5
CRH
CRY2
CSF1
CST2
CST9L
CTNNBIP1
CTSG
CTSZ
CXCL16
CXCL5
CYHR1
CYP21A2
CYSRT1
DAGLB
DALRD3
DBH
DGCR6
DGKQ
DHRS1
DMRT3
DNAL4
DOCK2
DRD5
EFNA3
EIF4E2
ELANE
EMC7
EPHB6
ESR2
F10
FAAH
FADS2
FAM124B
FAM221A
FAM71C
FAM71E2
FAM74A4
FAM90A1
FARS2
FASLG
FBXL18
FBXW5
FOXB1
FRS3
FTHL17
FZD10
GABRD
GATA2
GEM
GFOD1
GIP
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GNMT
GSTP1
GTF3C5
H2AC15
HAPLN2
HBA1
HBA2
HBZ
HCK
HHEX
HOXA1
HOXB9
HOXC8
HPCAL1
HSBP1
HSD3B7
HSPA12B
HSPBP1
HSPD1
ICAM4
IFI30
IL10
IL2RG
INO80B
INPP5D
INS
ITGB2
ITGB4
ITGB5
JOSD1
KCNS2
KCTD15
KIF1A
KLHL38
KLK8
KPRP
KRT20
KRT83
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LIMS2
LIN7A
LINC00526
LINC00656
LMNTD2
LMO2
LNX1
LONRF3
LRCH4
LRFN4
LYVE1
MACO1
MAPKBP1
MARK4
MATN3
MELTF
MFSD13A
MOS
MRGBP
MRPL40
MTA1
MVP
MXD3
MXI1
MYO15B
MYPOP
NAB2
NAXD
NECTIN2
NECTIN3
NEDD9
NEU2
NMU
NMUR2
NPBWR2
NPDC1
NPPB
NR1D2
NTM
NTN4
NUBP2
OLFM2
OTX1
P2RX4
P2RX7
P2RY6
PCED1A
PCED1B
PCSK5
PDE9A
PGAP6
PGLS
PHLDA1
PID1
PIGS
PLEKHN1
PLPP2
PLSCR4
POLR2G
POM121L8P
POMGNT2
PRF1
PRKAA2
PRPF31
PRPS2
PRR35
PSMA1
PSMG2
PTGER3
PTK7
PTPMT1
PTPN23
PVR
QPRT
R3HDM2
RAB3IL1
RAMP3
RASD1
RCHY1
RECK
RET
RGL2
RNF111
RPS19BP1
RPS28
RTN4RL1
SCNM1
SDCBP
SELENOM
SEMA3B
SEMA4C
SHFL
SLC22A23
SLC22A5
SLC23A1
SLC25A10
SLC25A6
SLC43A2
SLC5A5
SLC6A20
SMARCD2
SMARCE1
SMCP
SMOC1
SNAI1
SPATA24
SPATA8
SPG7
SPINK2
SPPL2C
SPRY1
STAC
STK16
TAPBPL
TBC1D10C
TBC1D16
TCAF1
TEDC2
THAP7
THEMIS2
TINAGL1
TLE5
TMEFF2
TMEM150A
TMEM231
TMEM41A
TMIE
TNIP3
TNK2
TNP2
TNS2
TRAPPC14
TRIM27
TRIM42
TROAP
TRPV6
TSPAN4
TTPA
TXNDC5
UBQLN4
UTP23
UXT
VASN
WDR25
WT1-AS
XCL2
YIPF3
ZDHHC1
ZFYVE21
ZNF124
ZNF319
ZNF32
ZNF330
ZNF408
ZNF414
ZNF417
ZNF439
ZNF440
ZNF446
ZNF497
ZNF580
ZNF581
ZNF587
ZNF648
ZNF672
ZNF688
ZNF786
ZNF837
122 interacting genes:
ABI1
ABI2
ACACA
ACACB
AIMP2
AKAP8L
AMOT
AMOTL2
ANAPC11
APPBP2
ARRDC3
AVPI1
C19orf47
CALCOCO1
CALCOCO2
CCDC172
CCDC33
CCNB1IP1
CDC42EP1
CDR2
CDX4
CPSF7
CTAG2
CYSRT1
DNAAF6
DNM2
DNMT1
DVL3
EEF2K
EMILIN1
EPM2A
EPN2
FNDC3B
FOS
GIGYF1
GLI1
GOLGA2
GOLGA6A
GRAP2
HAT1
HMBOX1
HNF4A
HOMEZ
IKZF1
IKZF3
KCTD1
KCTD9
KIAA1328
KIF16B
KIF24
KIFC3
KRT16
KRT31
KRTAP1-3
KRTAP10-3
KRTAP10-9
L3MBTL3
LCN2
LEP
LZTS2
MKRN3
MORN3
MRFAP1
MTUS2
MYCL
MYOZ1
NAB2
NECAB2
NONO
NOTCH2NLA
NRAP
NRBF2
NUTM1
PBXIP1
PFKFB2
PLEKHN1
PPP1R32
PRDM6
PRKAB1
PRKAG1
PRKAR1B
PRKN
PRPH
RASAL3
RBBP7
RBPMS
REL
RFX6
RPTOR
SERTAD3
SKIV2L
SLA2
SNW1
SOHLH1
SPRY1
STAC2
STK11
TCF4
TFAP2A
TIFA
TLE5
TMOD1
TRIP13
TRIP6
TSC22D4
UBE2I
USH1C
USH1G
USHBP1
USP10
VPS28
VPS37B
VPS52
WASHC1
WWP1
WWP2
YPEL3
ZBTB8A
ZMYND12
ZNF212
ZNF397
ZSCAN23
Entrez ID
388677
5563
HPRD ID
14833
02735
Ensembl ID
ENSG00000264343
ENSG00000162409
Uniprot IDs
P0DPK4
Q7Z3S9
P54646
PDB IDs
2H6D
2LTU
2YZA
3AQV
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6B2E
6BX6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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