NOTCH2NLA and DGKQ

Data Source:
BioGRID (two hybrid)

		NOTCH2NLA	DGKQ
Description		notch 2 N-terminal like A	diacylglycerol kinase theta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Nuclear Matrix Nuclear Speck Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Activating Transcription Factor Binding Phospholipase Binding Metal Ion Binding
	Biological Process	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway	Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Phosphatidic Acid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity G Protein-coupled Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-serine Phosphorylation CAMP-mediated Signaling Platelet Activation Response To ATP Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To CAMP Thrombin-activated Receptor Signaling Pathway Protein Kinase C Signaling Regulation Of Cholesterol Metabolic Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of TORC1 Signaling Regulation Of Cortisol Biosynthetic Process Regulation Of Progesterone Biosynthetic Process
Pathways			Effects of PIP2 hydrolysis
Drugs			alpha-Tocopherol succinate
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Idiopathic inflammatory myopathy ( 26362759) Limited cutaneous systemic scleroderma ( 29293537) Parkinson's disease ( 22451204 25064009 28892059 22438815 20070850 32310270) Parkinson's disease (familial) ( 18985386) Primary biliary cholangitis ( 26394269) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 28714469) Systemic sclerosis ( 31672989 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels ( 32203549) Waist circumference ( 31928498)
Interacting Genes		357 interacting genes: ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADCK5 AGXT ALDH16A1 ALDH3B1 ALPI ALPP ANKS1A AQP1 AQP5 ARID3A ASPSCR1 ATG9A ATP5F1D BCAM BCL6B BLCAP BMP7 BRME1 C11orf87 C5orf60 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CELF5 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A CNNM3 COL8A1 CRACR2A CRCT1 CREB5 CRH CRY2 CSF1 CST2 CST9L CTNNBIP1 CTSG CTSZ CXCL16 CXCL5 CYHR1 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGCR6 DGKQ DHRS1 DMRT3 DNAL4 DOCK2 DRD5 EFNA3 EIF4E2 ELANE EMC7 EPHB6 ESR2 F10 FAAH FADS2 FAM124B FAM221A FAM71C FAM71E2 FAM74A4 FAM90A1 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 FTHL17 FZD10 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL10 IL2RG INO80B INPP5D INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KIF1A KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIMS2 LIN7A LINC00526 LINC00656 LMNTD2 LMO2 LNX1 LONRF3 LRCH4 LRFN4 LYVE1 MACO1 MAPKBP1 MARK4 MATN3 MELTF MFSD13A MOS MRGBP MRPL40 MTA1 MVP MXD3 MXI1 MYO15B MYPOP NAB2 NAXD NECTIN2 NECTIN3 NEDD9 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NTM NTN4 NUBP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCED1A PCED1B PCSK5 PDE9A PGAP6 PGLS PHLDA1 PID1 PIGS PLEKHN1 PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRF1 PRKAA2 PRPF31 PRPS2 PRR35 PSMA1 PSMG2 PTGER3 PTK7 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RASD1 RCHY1 RECK RET RGL2 RNF111 RPS19BP1 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA3B SEMA4C SHFL SLC22A23 SLC22A5 SLC23A1 SLC25A10 SLC25A6 SLC43A2 SLC5A5 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA24 SPATA8 SPG7 SPINK2 SPPL2C SPRY1 STAC STK16 TAPBPL TBC1D10C TBC1D16 TCAF1 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEFF2 TMEM150A TMEM231 TMEM41A TMIE TNIP3 TNK2 TNP2 TNS2 TRAPPC14 TRIM27 TRIM42 TROAP TRPV6 TSPAN4 TTPA TXNDC5 UBQLN4 UTP23 UXT VASN WDR25 WT1-AS XCL2 YIPF3 ZDHHC1 ZFYVE21 ZNF124 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF688 ZNF786 ZNF837	3 interacting genes: NBPF19 NOTCH2NLA RHOA
Entrez ID		388677	1609
HPRD ID		14833	03127
Ensembl ID		ENSG00000264343	ENSG00000145214
Uniprot IDs		P0DPK4 Q7Z3S9	A0A140VKC1 P52824 Q59FF7
PDB IDs
Enriched GO Terms of Interacting Partners?
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