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KRAS and CCL5
Data Source:
BioGRID
(two hybrid)
KRAS
CCL5
Description
KRAS proto-oncogene, GTPase
C-C motif chemokine ligand 5
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Membrane Raft
Extracellular Region
Extracellular Space
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GMP Binding
GDP Binding
LRR Domain Binding
Protein-containing Complex Binding
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Biological Process
MAPK Cascade
Liver Development
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Ras Protein Signal Transduction
Female Pregnancy
Positive Regulation Of Cell Population Proliferation
Visual Learning
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Forebrain Astrocyte Development
Actin Cytoskeleton Organization
Regulation Of Protein Stability
Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Rac Protein Signal Transduction
Response To Isolation Stress
Endocrine Signaling
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Differentiation
Regulation Of Long-term Neuronal Synaptic Plasticity
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Response To Mineralocorticoid
Epithelial Tube Branching Involved In Lung Morphogenesis
Positive Regulation Of Cellular Senescence
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
RUNX3 regulates p14-ARF
RAS processing
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
Farnesyl diphosphate
MRTX849
AMG-510
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Diseases
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
Pancreatic cancer
Gastric cancer
Colorectal cancer
Non-small cell lung cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Oral cancer
Acute myeloid leukemia (AML)
Endometrial Cancer
Multiple myeloma
Squamous cell carcinoma
Kaposi's sarcoma
Cholangiocarcinoma
Thyroid cancer
Cervical cancer
Hepatocellular carcinoma
Ovarian cancer
Gallbladder cancer
GWAS
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Dysmenorrheic pain (
27454463
)
Blood protein levels (
30072576
28240269
)
Interacting Genes
63 interacting genes:
ADH6
ARAF
ARL6IP5
BCAS3
BCL2
BRAF
CALM1
CCL5
CCT7
CDK8
DDX47
DDX50
DIRAS3
DNAJA3
EGLN1
EPB42
FANCC
FNTA
FNTB
FRAT2
HEMGN
HNRNPC
HRAS
IGFBP3
IGSF21
IL24
LPAR1
LYPD4
LZTR1
MDFI
MOCS2
MT-CO3
MT-CYB
NDUFA13
OSGIN1
PDE4DIP
PGGT1B
PIK3CA
PIK3CG
PIK3R2
PIP5K1A
PPP2CB
PSMA3
QDPR
RAF1
RALGDS
RAP1GDS1
RASGRF2
RASGRP2
RASSF2
RASSF5
RBPMS
RGL2
SERPINB5
SHOC2
SOX4
STX17
THRSP
TNFSF13
UQCRC1
WDR76
ZDHHC17
ZNF189
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
Entrez ID
3845
6352
HPRD ID
01817
01751
Ensembl ID
ENSG00000133703
ENSG00000271503
Uniprot IDs
A0A024RAV5
I1SRC5
L7RSL8
P01116
A0A494C1Q1
D0EI67
P13501
PDB IDs
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
2MSC
2MSD
2MSE
3GFT
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5MLA
5MLB
5O2S
5O2T
5OCG
5OCO
5OCT
5TAR
5TB5
5UFE
5UFQ
5UK9
5UQW
5US4
5USJ
5V6S
5V6V
5V71
5V9L
5V9O
5V9U
5VBM
5VP7
5VPI
5VPY
5VPZ
5VQ0
5VQ1
5VQ2
5VQ6
5VQ8
5W22
5WHA
5WHB
5WHD
5WHE
5WLB
5WPM
5XCO
5YXZ
5YY1
6ARK
6ASA
6ASE
6B0V
6B0Y
6BOF
6BP1
6CC9
6CCH
6CCX
6CU6
6E6F
6E6G
6EPL
6EPM
6EPN
6EPO
6EPP
6F76
6FA1
6FA2
6FA3
6FA4
6GJ5
6GJ6
6GJ7
6GJ8
6GOD
6GOE
6GOF
6GOG
6GOM
6GQT
6GQW
6GQX
6GQY
6H46
6H47
6JTN
6JTO
6JTP
6M9W
6MBQ
6MBT
6MBU
6MNX
6MQG
6MQN
6MS9
6MTA
6N2J
6N2K
6O36
6O46
6O4Y
6O4Z
6O51
6O53
6OB2
6OB3
6OIM
6P0Z
6P8W
6P8X
6P8Y
6P8Z
6PGO
6PGP
6PQ3
6PTS
6PTW
6QUU
6QUV
6QUW
6QUX
6T5B
6T5U
6T5V
6TAM
6TAN
6USX
6USZ
6UT0
6V5L
6V65
6V6F
6W4E
6W4F
6WGN
6YR8
6YXW
6ZL5
6ZLI
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
Enriched GO Terms of Interacting Partners
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