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KRAS and PDE4DIP
Data Source:
BioGRID
(two hybrid)
KRAS
PDE4DIP
Description
KRAS proto-oncogene, GTPase
phosphodiesterase 4D interacting protein
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Membrane Raft
Nucleus
Cytoplasm
Golgi Apparatus
Centrosome
Myofibril
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GMP Binding
GDP Binding
LRR Domain Binding
Protein-containing Complex Binding
Protein Binding
Enzyme Binding
Molecular Adaptor Activity
Biological Process
MAPK Cascade
Liver Development
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Ras Protein Signal Transduction
Female Pregnancy
Positive Regulation Of Cell Population Proliferation
Visual Learning
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Forebrain Astrocyte Development
Actin Cytoskeleton Organization
Regulation Of Protein Stability
Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Rac Protein Signal Transduction
Response To Isolation Stress
Endocrine Signaling
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Differentiation
Regulation Of Long-term Neuronal Synaptic Plasticity
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Response To Mineralocorticoid
Epithelial Tube Branching Involved In Lung Morphogenesis
Positive Regulation Of Cellular Senescence
Cellular Protein-containing Complex Assembly
Regulation Of Golgi Organization
Pathways
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
RUNX3 regulates p14-ARF
RAS processing
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Drugs
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
Farnesyl diphosphate
MRTX849
AMG-510
Diseases
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
Pancreatic cancer
Gastric cancer
Colorectal cancer
Non-small cell lung cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Oral cancer
Acute myeloid leukemia (AML)
Endometrial Cancer
Multiple myeloma
Squamous cell carcinoma
Kaposi's sarcoma
Cholangiocarcinoma
Thyroid cancer
Cervical cancer
Hepatocellular carcinoma
Ovarian cancer
Gallbladder cancer
GWAS
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Dysmenorrheic pain (
27454463
)
Capecitabine sensitivity (
22864933
)
Interacting Genes
63 interacting genes:
ADH6
ARAF
ARL6IP5
BCAS3
BCL2
BRAF
CALM1
CCL5
CCT7
CDK8
DDX47
DDX50
DIRAS3
DNAJA3
EGLN1
EPB42
FANCC
FNTA
FNTB
FRAT2
HEMGN
HNRNPC
HRAS
IGFBP3
IGSF21
IL24
LPAR1
LYPD4
LZTR1
MDFI
MOCS2
MT-CO3
MT-CYB
NDUFA13
OSGIN1
PDE4DIP
PGGT1B
PIK3CA
PIK3CG
PIK3R2
PIP5K1A
PPP2CB
PSMA3
QDPR
RAF1
RALGDS
RAP1GDS1
RASGRF2
RASGRP2
RASSF2
RASSF5
RBPMS
RGL2
SERPINB5
SHOC2
SOX4
STX17
THRSP
TNFSF13
UQCRC1
WDR76
ZDHHC17
ZNF189
85 interacting genes:
ADH1B
AEN
AKTIP
ANKRD11
ARNT2
BYSL
C1orf109
CCDC146
CCDC198
CDC5L
CDKN1A
CHCHD3
CLIP4
CWF19L2
EGR2
FAM161A
FAM50B
FAM74A4
FCHSD2
FES
FHL1
GADD45G
GFI1B
GOLGA8EP
GOLGA8F
HAUS1
HOXB5
HOXC8
ITSN2
KDM1A
KLC3
KLC4
KRAS
KRT18
KRT31
LAMTOR3
LENG1
LIN37
LMO4
MAPRE3
MIF4GD
MTUS2
MYBPC2
MYOM1
NAA10
NEFL
NEK2
OSGEP
PDE4D
PEA15
PFDN1
PIAS4
PPP1R18
PRNP
PRPF31
PYGM
RTP5
SCNM1
SDCBP
SH2D4A
SHFL
SMN1
SNCA
TEAD4
TFIP11
TK1
TNIK
TRAF4
TULP3
UTP14C
VAC14
ZBTB24
ZBTB38
ZBTB4
ZFYVE21
ZKSCAN3
ZNF124
ZNF408
ZNF410
ZNF414
ZNF512B
ZNF581
ZNF587
ZNF696
ZSCAN26
Entrez ID
3845
9659
HPRD ID
01817
10482
Ensembl ID
ENSG00000133703
ENSG00000178104
Uniprot IDs
A0A024RAV5
I1SRC5
L7RSL8
P01116
A0A075B749
A0A087WYE4
Q5VU43
PDB IDs
1D8D
1D8E
1KZO
1KZP
1N4P
1N4Q
1N4R
1N4S
2MSC
2MSD
2MSE
3GFT
4DSN
4DSO
4EPR
4EPT
4EPV
4EPW
4EPX
4EPY
4L8G
4LDJ
4LPK
4LRW
4LUC
4LV6
4LYF
4LYH
4LYJ
4M1O
4M1S
4M1T
4M1W
4M1Y
4M21
4M22
4NMM
4OBE
4PZY
4PZZ
4Q01
4Q02
4Q03
4QL3
4TQ9
4TQA
4WA7
5F2E
5KYK
5MLA
5MLB
5O2S
5O2T
5OCG
5OCO
5OCT
5TAR
5TB5
5UFE
5UFQ
5UK9
5UQW
5US4
5USJ
5V6S
5V6V
5V71
5V9L
5V9O
5V9U
5VBM
5VP7
5VPI
5VPY
5VPZ
5VQ0
5VQ1
5VQ2
5VQ6
5VQ8
5W22
5WHA
5WHB
5WHD
5WHE
5WLB
5WPM
5XCO
5YXZ
5YY1
6ARK
6ASA
6ASE
6B0V
6B0Y
6BOF
6BP1
6CC9
6CCH
6CCX
6CU6
6E6F
6E6G
6EPL
6EPM
6EPN
6EPO
6EPP
6F76
6FA1
6FA2
6FA3
6FA4
6GJ5
6GJ6
6GJ7
6GJ8
6GOD
6GOE
6GOF
6GOG
6GOM
6GQT
6GQW
6GQX
6GQY
6H46
6H47
6JTN
6JTO
6JTP
6M9W
6MBQ
6MBT
6MBU
6MNX
6MQG
6MQN
6MS9
6MTA
6N2J
6N2K
6O36
6O46
6O4Y
6O4Z
6O51
6O53
6OB2
6OB3
6OIM
6P0Z
6P8W
6P8X
6P8Y
6P8Z
6PGO
6PGP
6PQ3
6PTS
6PTW
6QUU
6QUV
6QUW
6QUX
6T5B
6T5U
6T5V
6TAM
6TAN
6USX
6USZ
6UT0
6V5L
6V65
6V6F
6W4E
6W4F
6WGN
6YR8
6YXW
6ZL5
6ZLI
Enriched GO Terms of Interacting Partners
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