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ITGA5 and L1CAM
Data Source:
HPRD
(in vitro)
ITGA5
L1CAM
Description
integrin subunit alpha 5
L1 cell adhesion molecule
Image
No pdb structure
GO Annotations
Cellular Component
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Molecular Function
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Biological Process
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Pathways
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Drugs
Resveratrol
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GPR182
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
Entrez ID
3678
3897
HPRD ID
00627
02394
Ensembl ID
ENSG00000161638
ENSG00000198910
Uniprot IDs
B2R627
P08648
P32004
PDB IDs
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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