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ITGA5 and ANGPT1
Data Source:
HPRD
(in vitro)
ITGA5
ANGPT1
Description
integrin subunit alpha 5
angiopoietin 1
Image
GO Annotations
Cellular Component
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Microvillus
Membrane Raft
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Signaling Receptor Binding
Receptor Tyrosine Kinase Binding
Biological Process
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
MAPK Cascade
Angiogenesis
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Positive Regulation Of Receptor Internalization
Negative Regulation Of Cytokine Production Involved In Immune Response
Negative Regulation Of Cell Adhesion
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Skeletal Muscle Satellite Cell Proliferation
Hemopoiesis
Cell Differentiation
Heparin Biosynthetic Process
Positive Regulation Of Protein Ubiquitination
Cell-substrate Adhesion
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Protein Localization To Cell Surface
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Negative Regulation Of Vascular Permeability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Cell Adhesion
Tie Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Glomerulus Vasculature Development
Positive Regulation Of Blood-brain Barrier Permeability
Negative Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
Tie2 Signaling
Tie2 Signaling
RAF/MAP kinase cascade
Drugs
Resveratrol
Diseases
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Blood protein levels (
30072576
)
Body mass index (
28552196
)
Brain morphology (MOSTest) (
32665545
)
Corneal astigmatism (
29422769
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Face memory (
31596458
)
Fractional exhaled nitric oxide (childhood) (
24315451
)
Glaucoma (
31959993
30054594
)
Glaucoma (primary open-angle) (
29891935
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
27863252
)
Intraocular pressure (
29617998
29785010
31959993
30054594
29235454
)
Male-pattern baldness (
28196072
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (antiglaucoma preparations and miotics) (
31015401
)
Periventricular white matter hyperintensities (
32517579
)
Platelet distribution width (
32888494
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GPR182
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
4 interacting genes:
ANGPT2
ITGA5
TEK
TIE1
Entrez ID
3678
284
HPRD ID
00627
03392
Ensembl ID
ENSG00000161638
ENSG00000154188
Uniprot IDs
B2R627
P08648
B4DTQ9
Q15389
PDB IDs
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
4EPU
4JYO
4K0V
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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