ITGA5 and NISCH

Data Source:
HPRD (in vivo, in vitro)

		ITGA5	NISCH
Description		integrin subunit alpha 5	nischarin
Image
GO Annotations	Cellular Component	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Alphav-beta3 Integrin-vitronectin Complex	Nucleoplasm Cytoplasm Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Intercellular Bridge Recycling Endosome
	Molecular Function	Virus Receptor Activity Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Integrin Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Positive Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Glucose Metabolic Process Apoptotic Process Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration
Drugs		Resveratrol	Tizanidine Agmatine Moxonidine
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Triglyceride levels ( 32203549) Waist-hip ratio ( 20935629)
Interacting Genes		31 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL	4 interacting genes: AR IRS4 ITGA5 PTGER4
Entrez ID		3678	11188
HPRD ID		00627	11391
Ensembl ID		ENSG00000161638	ENSG00000010322
Uniprot IDs		B2R627 P08648	Q9Y2I1
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4	3P0C
Enriched GO Terms of Interacting Partners?
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