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ITGA5 and FLT4
Data Source:
HPRD
(in vitro)
ITGA5
FLT4
Description
integrin subunit alpha 5
fms related receptor tyrosine kinase 4
Image
GO Annotations
Cellular Component
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Molecular Function
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Phosphatase Binding
Protein Homodimerization Activity
Biological Process
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Lymphangiogenesis
Sprouting Angiogenesis
Hematopoietic Progenitor Cell Differentiation
Respiratory System Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Kinase Activity
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Blood Vessel Morphogenesis
Regulation Of Blood Vessel Remodeling
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Kinase C Signaling
Pathways
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
VEGF binds to VEGFR leading to receptor dimerization
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Resveratrol
Sorafenib
Sunitinib
Vatalanib
TG-100801
Denibulin
ABT-869
IMC-1C11
Pazopanib
Axitinib
Regorafenib
Lenvatinib
Nintedanib
Fostamatinib
Selpercatinib
Diseases
Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Blood protein levels (
30072576
29875488
)
Platelet distribution width (
32888494
)
Serum folate levels (
29953918
)
Interacting Genes
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GPR182
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
16 interacting genes:
ATF7IP
DUSP19
ERBB2
GRB2
IKBKG
ITGA5
ITGB1
KDR
LRRK1
NEDD4
PTK2
PTPN11
SHC1
SHC3
VEGFC
VEGFD
Entrez ID
3678
2324
HPRD ID
00627
00636
Ensembl ID
ENSG00000161638
ENSG00000037280
Uniprot IDs
B2R627
P08648
P35916
PDB IDs
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
4BSJ
4BSK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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