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ITGA5 and ITGB1
Data Source:
HPRD
(in vitro, in vivo)
ITGA5
ITGB1
Description
integrin subunit alpha 5
integrin subunit beta 1
Image
GO Annotations
Cellular Component
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Ruffle
Cytoplasm
Plasma Membrane
Focal Adhesion
Integrin Complex
Cell Surface
Membrane
Lamellipodium
Filopodium
Neuromuscular Junction
Cleavage Furrow
Ruffle Membrane
Integrin Alpha1-beta1 Complex
Integrin Alpha2-beta1 Complex
Integrin Alpha3-beta1 Complex
Integrin Alpha4-beta1 Complex
Integrin Alpha5-beta1 Complex
Integrin Alpha8-beta1 Complex
Integrin Alpha10-beta1 Complex
Integrin Alpha11-beta1 Complex
Sarcolemma
Melanosome
Receptor Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Recycling Endosome
Extracellular Exosome
Glial Cell Projection
Molecular Function
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Virus Receptor Activity
Fibronectin Binding
Protease Binding
Actin Binding
Integrin Binding
Protein Binding
Coreceptor Activity
C-X3-C Chemokine Binding
Laminin Binding
Protein-containing Complex Binding
Cadherin Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Collagen Binding Involved In Cell-matrix Adhesion
Protein Tyrosine Kinase Binding
Biological Process
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Establishment Of Mitotic Spindle Orientation
Phagocytosis
Cellular Defense Response
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Collagen Catabolic Process
Positive Regulation Of Fibroblast Migration
Cell Migration
Cytokine-mediated Signaling Pathway
CD40 Signaling Pathway
Cell Projection Organization
Lamellipodium Assembly
B Cell Differentiation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Receptor Internalization
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Maintenance Of Blood-brain Barrier
Positive Regulation Of Apoptotic Process
Stress Fiber Assembly
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Viral Entry Into Host Cell
Mesodermal Cell Differentiation
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Wound Healing
Regulation Of Spontaneous Synaptic Transmission
Reactive Gliosis
Regulation Of Inward Rectifier Potassium Channel Activity
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Anoikis
Pathways
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
MET activates PTK2 signaling
MET interacts with TNS proteins
HCMV Early Events
Potential therapeutics for SARS
Drugs
Resveratrol
Antithymocyte immunoglobulin (rabbit)
MK-0668
Diseases
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Depression (quantitative trait) (
20800221
)
Suicide in bipolar disorder (
25917933
)
Interacting Genes
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GPR182
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
76 interacting genes:
ACAP1
ACTN1
ACTN4
ARHGAP5
CANX
CD151
CD36
CD46
CD82
CD9
CRKL
DAG1
DOK1
EGFR
ENO1
EPS8
FBLN1
FBXO2
FERMT1
FERMT2
FERMT3
FHL2
FLNA
FLNB
FLT4
FN1
HSPD1
HSPG2
ICAM4
IGF1R
ILK
ITGA1
ITGA10
ITGA11
ITGA2
ITGA3
ITGA4
ITGA5
ITGA6
ITGA8
ITGA9
ITGAV
ITGB1BP1
ITGB1BP2
LAMA1
LAMTOR5
LGALS1
LGALS3BP
LGALS8
MAP4K4
MET
NCKIPSD
NF2
NGF
NME1
NMRK2
PDHB
PIP5K1C
PLAUR
PRKCA
PRKCE
PTK2
PXN
RAB25
RACK1
SLC3A2
SPP1
TGM2
TGOLN2
TIMP2
TLN1
TSPAN4
UPF2
VCAM1
VCAN
YWHAB
Entrez ID
3678
3688
HPRD ID
00627
00628
Ensembl ID
ENSG00000161638
ENSG00000150093
Uniprot IDs
B2R627
P08648
P05556
PDB IDs
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
1K11
1LHA
3G9W
3T9K
3VI3
3VI4
4DX9
4WJK
4WK0
4WK2
4WK4
Enriched GO Terms of Interacting Partners
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