L1CAM and NCAM1

Data Source:
HPRD (in vitro)

		L1CAM	NCAM1
Description		L1 cell adhesion molecule	neural cell adhesion molecule 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Axonal Growth Cone Collagen-containing Extracellular Matrix	Golgi Membrane Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Neuron Projection Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding	Virus Receptor Activity Protein Binding
	Biological Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Leukocyte Migration Axon Development	MAPK Cascade Cell Adhesion Axon Guidance Viral Entry Into Host Cell Interferon-gamma-mediated Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1	ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling
Drugs		Ethanol
Diseases		Hereditary spastic paraplegia (SPG) Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS			Age at first sexual intercourse ( 27089180) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Cannabis use ( 30150663 27023175) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Heel bone mineral density ( 30598549 28869591) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878)
Interacting Genes		24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2	19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		3897	4684
HPRD ID		02394	00301
Ensembl ID		ENSG00000198910	ENSG00000149294
Uniprot IDs		P32004	A0A087WWD4 P13591
PDB IDs			2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN
Enriched GO Terms of Interacting Partners?
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