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L1CAM and NRP1
Data Source:
BioGRID
(two hybrid)
L1CAM
NRP1
Description
L1 cell adhesion molecule
neuropilin 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Semaphorin Receptor Complex
Extracellular Space
Early Endosome
Cytosol
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Growth Cone
Cytoplasmic Vesicle
Mitochondrial Membrane
Neuron Projection
Neuronal Cell Body
Receptor Complex
Sorting Endosome
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Vascular Endothelial Growth Factor-activated Receptor Activity
GTPase Activator Activity
Protein Binding
Heparin Binding
Coreceptor Activity
Semaphorin Receptor Activity
Growth Factor Binding
Cytokine Binding
Vascular Endothelial Growth Factor Binding
Metal Ion Binding
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Neuron Migration
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Cell Migration Involved In Sprouting Angiogenesis
Outflow Tract Septum Morphogenesis
Substrate-dependent Cell Migration, Cell Extension
Signal Transduction
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Axon Guidance
Response To Wounding
Animal Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Smooth Muscle Cell Migration
Nerve Development
Retinal Ganglion Cell Axon Guidance
Actin Cytoskeleton Reorganization
Regulation Of Cdc42 Protein Signal Transduction
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Hepatocyte Growth Factor Stimulus
Endothelial Cell Chemotaxis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Neuropilin Signaling Pathway
VEGF-activated Neuropilin Signaling Pathway
Positive Regulation Of Phosphorylation
Endothelial Cell Migration
Positive Regulation Of GTPase Activity
Viral Entry Into Host Cell
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Positive Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Axon Extension Involved In Axon Guidance
Artery Morphogenesis
Axon Extension Involved In Axon Guidance
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Cytokine Activity
Axonogenesis Involved In Innervation
Regulation Of Vesicle-mediated Transport
Angiogenesis Involved In Coronary Vascular Morphogenesis
Retina Vasculature Morphogenesis In Camera-type Eye
Sympathetic Ganglion Development
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Commissural Neuron Axon Guidance
Regulation Of Retinal Ganglion Cell Axon Guidance
Endothelial Tip Cell Fate Specification
Motor Neuron Migration
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Basal Dendrite Development
Basal Dendrite Arborization
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Positive Regulation Of Retinal Ganglion Cell Axon Guidance
Protein Localization To Early Endosome
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Neurophilin interactions with VEGF and VEGFR
Signaling by ROBO receptors
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Signal transduction by L1
CHL1 interactions
Drugs
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS
Apolipoprotein A1 levels (
32203549
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
29212778
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol levels (
32203549
)
Migraine (
27322543
)
Reticulocyte count (
32888494
)
Schizophrenia (
21682944
)
Small cell lung carcinoma (
28604730
)
Tetralogy of Fallot (
23297363
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
23 interacting genes:
FGF1
FGF2
FGF4
FGF7
FGFR1
FLT1
GIPC1
KDR
L1CAM
NRP2
PGF
PLXNA1
PLXNB1
RPL27
SEMA3A
SEMA3B
SEMA3C
SEMA3F
TGFBR1
TGFBR2
TGFBR3
VEGFA
VEGFB
Entrez ID
3897
8829
HPRD ID
02394
03642
Ensembl ID
ENSG00000198910
ENSG00000099250
Uniprot IDs
P32004
A8K9V7
O14786
Q59F20
Q68DN3
Q6AWA9
Q6X907
PDB IDs
1KEX
2QQI
2QQM
2QQN
3I97
4DEQ
4RN5
5C7G
5IJR
5IYY
5J1X
5JGI
5JGQ
5JHK
5L73
6FMC
6FMF
7JJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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