Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
SERPINE1 and TLX3
Data Source:
BioGRID
(two hybrid)
SERPINE1
TLX3
Description
serpin family E member 1
T cell leukemia homeobox 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Molecular Function
Protease Binding
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Angiogenesis
Platelet Degranulation
Circadian Rhythm
Regulation Of Signaling Receptor Activity
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Blood Coagulation
Negative Regulation Of Blood Coagulation
Extracellular Matrix Organization
Negative Regulation Of Cell Migration
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Leukotriene Production Involved In Inflammatory Response
Fibrinolysis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Negative Regulation Of Fibrinolysis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Replicative Senescence
Dentinogenesis
Positive Regulation Of Odontoblast Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Smooth Muscle Cell-matrix Adhesion
Negative Regulation Of Endothelial Cell Apoptotic Process
Neuron Migration
Regulation Of Respiratory Gaseous Exchange By Nervous System Process
Regulation Of Transcription By RNA Polymerase II
Central Nervous System Development
Respiratory Gaseous Exchange By Respiratory System
Negative Regulation Of Neuron Differentiation
Animal Organ Development
Neuron Fate Specification
Pathways
Platelet degranulation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
ECM proteoglycans
Dissolution of Fibrin Clot
Drugs
Alteplase
Urokinase
Reteplase
Anistreplase
Tenecteplase
Drotrecogin alfa
Troglitazone
Fibrinolysin
Copper
Diseases
Inherited thrombophilia
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Blood protein levels (
30072576
)
Nonunion in individuals with fractures (
30680360
)
Plasma plasminogen activator levels (
24578379
)
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Body size at age 10 (
32376654
)
Interacting Genes
25 interacting genes:
ACTN4
ELANE
F2
HSD17B11
IGFBP5
KLK2
KRT18
LMNA
LRP1
LRP1B
LRP2
MMP3
ORM1
PITX1
PLAT
PLAU
PLG
SGTA
SGTB
TLX3
TMEM237
UBQLN1
UBQLN2
UBQLN4
VTN
106 interacting genes:
ACY1
AKAP9
ANKRD10
ANKRD33
AOC1
APBB1IP
ARMC5
ASB12
ATP6V0D1
B9D2
BPIFA1
C11orf1
C11orf45
C19orf54
C2orf42
CEACAM6
CRX
CSNK2B
CTNNA3
DENND4A
EFEMP2
ERAS
FAM166B
FAM168B
FCSK
FNTB
FOSB
FOXH1
GGTLC2
GOLGA6L9
GTF2A1L
H2BC11
HNRNPUL1
HOPX
HSPB2
HSPB2-C11orf52
HYI
IGFL2
ING4
INTS11
IRF9
ITIH6
KRT34
KRTAP11-1
KRTAP13-3
KRTAP19-1
KRTAP19-7
KRTAP3-1
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LASP1
LMO2
MAGED1
MEIS1
METTL27
MORN5
MSX2
NDUFAB1
NHLRC4
NICN1
OIP5
PLA2G10
PLAAT1
POU2AF1
POU6F2
PPP1CC
PQBP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB11
REL
ROR2
RSKR
SERPINE1
SLC15A2
SMU1
SNTA1
SP1
SPATA46
SPRYD7
STH
SYNGAP1
TBX22
TCIRG1
TEKT5
TEX37
THTPA
TLE1
TLE2
TMEM42
TOX2
TP53BP1
TRIM42
UFSP1
WDR83
YPEL3
ZBTB32
ZNF34
ZNF41
ZNF44
Entrez ID
5054
30012
HPRD ID
01418
06868
Ensembl ID
ENSG00000106366
ENSG00000164438
Uniprot IDs
A0A024QYT5
P05121
O43711
PDB IDs
1A7C
1B3K
1C5G
1DB2
1DVM
1DVN
1LJ5
1OC0
3CVM
3EOX
3PB1
3Q02
3Q03
3R4L
3UT3
4AQH
4G8O
4G8R
4IC0
5BRR
5ZLZ
6GWN
6GWP
6GWQ
6I8S
6ZRV
9PAI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?