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SERPINE1 and LRP1
Data Source:
HPRD
(in vivo, in vitro)
SERPINE1
LRP1
Description
serpin family E member 1
LDL receptor related protein 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Nucleus
Lysosomal Membrane
Early Endosome
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Dendrite
Endocytic Vesicle Membrane
Insulin-responsive Compartment
Neuronal Cell Body
Receptor Complex
Axonal Growth Cone
Apical Part Of Cell
Plasma Membrane Protein Complex
Postsynaptic Golgi Apparatus
Molecular Function
Protease Binding
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Amyloid-beta Binding
Protease Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Coreceptor Activity
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Lipoprotein Particle Receptor Binding
Biological Process
Angiogenesis
Platelet Degranulation
Circadian Rhythm
Regulation Of Signaling Receptor Activity
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Blood Coagulation
Negative Regulation Of Blood Coagulation
Extracellular Matrix Organization
Negative Regulation Of Cell Migration
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Leukotriene Production Involved In Inflammatory Response
Fibrinolysis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Negative Regulation Of Fibrinolysis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Replicative Senescence
Dentinogenesis
Positive Regulation Of Odontoblast Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Smooth Muscle Cell-matrix Adhesion
Negative Regulation Of Endothelial Cell Apoptotic Process
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Aging
Cell Population Proliferation
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Cell Death
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Smooth Muscle Cell Migration
Cerebral Cortex Development
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Protein Binding
Positive Regulation Of Lipid Transport
Regulation Of Cholesterol Transport
Regulation Of Phospholipase A2 Activity
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Aorta Morphogenesis
Lipoprotein Metabolic Process
Lipoprotein Transport
Apoptotic Cell Clearance
Negative Regulation Of Neuron Apoptotic Process
Cellular Lipid Catabolic Process
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Axon Extension Involved In Regeneration
Positive Regulation Of Collateral Sprouting Of Injured Axon
Positive Regulation Of Phagocytosis
Negative Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Focal Adhesion Assembly
Chemoattraction Of Axon
Positive Regulation Of ERK1 And ERK2 Cascade
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Transport Across Blood-brain Barrier
Positive Regulation Of Schwann Cell Migration
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cholesterol Import
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Metallopeptidase Activity
Positive Regulation Of Lysosomal Protein Catabolic Process
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways
Platelet degranulation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
ECM proteoglycans
Dissolution of Fibrin Clot
Scavenging of heme from plasma
Retinoid metabolism and transport
Drugs
Alteplase
Urokinase
Reteplase
Anistreplase
Tenecteplase
Drotrecogin alfa
Troglitazone
Fibrinolysin
Copper
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Lanoteplase
Coagulation Factor IX Human
Lonoctocog alfa
Moroctocog alfa
Diseases
Inherited thrombophilia
GWAS
Blood protein levels (
30072576
)
Nonunion in individuals with fractures (
30680360
)
Plasma plasminogen activator levels (
24578379
)
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Abdominal aortic aneurysm (
27899403
22055160
)
Adult asthma (
30787307
)
Asthma (
31959851
27182965
31619474
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
22683712
27182965
23793025
21666692
27322543
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Spontaneous coronary artery dissection (
32887874
32374345
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
25961943
20686565
)
Interacting Genes
25 interacting genes:
ACTN4
ELANE
F2
HSD17B11
IGFBP5
KLK2
KRT18
LMNA
LRP1
LRP1B
LRP2
MMP3
ORM1
PITX1
PLAT
PLAU
PLG
SGTA
SGTB
TLX3
TMEM237
UBQLN1
UBQLN2
UBQLN4
VTN
70 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
BDNF
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NGF
NOS1AP
NTF3
NTF4
PDGFB
PID1
PLAT
PLAUR
PRKACA
PTPN11
RIC8B
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
Entrez ID
5054
4035
HPRD ID
01418
00138
Ensembl ID
ENSG00000106366
ENSG00000123384
Uniprot IDs
A0A024QYT5
P05121
Q07954
Q59FG2
PDB IDs
1A7C
1B3K
1C5G
1DB2
1DVM
1DVN
1LJ5
1OC0
3CVM
3EOX
3PB1
3Q02
3Q03
3R4L
3UT3
4AQH
4G8O
4G8R
4IC0
5BRR
5ZLZ
6GWN
6GWP
6GWQ
6I8S
6ZRV
9PAI
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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