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GPX8 and OCLN
Data Source:
BioGRID
(two hybrid)
GPX8
OCLN
Description
glutathione peroxidase 8 (putative)
occludin
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum Lumen
Integral Component Of Membrane
Lysosomal Membrane
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Integral Component Of Membrane
Apical Plasma Membrane
Apicolateral Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Endocytic Vesicle
Cell Leading Edge
Cytoplasmic Vesicle
Protein-containing Complex
Tight Junction
Molecular Function
Peroxidase Activity
Glutathione Peroxidase Activity
Protein Binding
Protein Binding
Protein Domain Specific Binding
Biological Process
Cellular Response To Oxidative Stress
Cellular Oxidant Detoxification
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Glucose Transmembrane Transport
Positive Regulation Of Microtubule Polymerization
Maintenance Of Blood-brain Barrier
Cell-cell Junction Organization
Positive Regulation Of Glucose Import
Protein-containing Complex Assembly
Response To Interleukin-18
Bicellular Tight Junction Assembly
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Wound Healing
Protein Localization To Cell Leading Edge
Positive Regulation Of Blood-brain Barrier Permeability
Regulation Of Bicellular Tight Junction Assembly
Pathways
Detoxification of Reactive Oxygen Species
Apoptotic cleavage of cell adhesion proteins
RUNX1 regulates expression of components of tight junctions
Drugs
Glutathione
Glutathione disulfide
Diseases
Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS
Cocaine dependence (
31212010
)
Hand grip strength (Mahalanobis distance) (
32235003
)
Interleukin-18 levels (
27989323
)
Interacting Genes
152 interacting genes:
-
AGTRAP
AIG1
ALG8
APOC3
APOD
AQP1
AQP2
AQP3
ASGR1
ASPH
BCL2L2
BET1
BIK
BMP10
BNIP2
BTN2A2
C14orf180
C1GALT1
CACNG1
CD302
CD53
CD81
CDIPT
CDS2
CFHR5
CHST1
CLDN19
CLEC1A
CLEC2A
CMTM5
CNIH1
CNIH3
COL4A5
COL8A2
CORIN
CYB561
CYB561A3
CYB561D2
DNAJC30
DOLK
EDDM3B
ERG28
ERO1A
FA2H
FAM3C
FAXDC2
GET3
GOSR2
GPR151
GPR37L1
GRINA
GYPA
HHATL
HMOX2
IGFBP5
INSIG2
KIR2DL3
KLRG1
LAPTM4B
LEPROTL1
LHFPL5
LNPEP
LPAR3
MAN2B2
MARCHF2
MARCHF5
MFSD5
MFSD6
MGST2
MGST3
MIP
MMD
MYADML2
NEU1
NINJ1
NIPAL3
NKG7
NRM
OCLN
PAEP
PAQR5
PAQR6
PGAP2
PLLP
PLN
PLP2
PLPP4
PLPP6
PNLIPRP1
PRB1
RBFA
RND1
RTP2
SCARB2
SCARF1
SCD
SEC22B
SELENOK
SERINC1
SERINC2
SERP1
SERTM1
SFTPC
SGMS2
SLC13A3
SLC30A3
SLC34A3
SLC35A1
SLC35B4
SLC41A2
SMAGP
SNORC
ST6GAL2
STX3
STX8
SYT15
TF
THBD
TIMMDC1
TM4SF4
TMBIM6
TMEM107
TMEM109
TMEM120B
TMEM128
TMEM14B
TMEM19
TMEM218
TMEM229B
TMEM243
TMEM254
TMEM42
TMEM50B
TMEM60
TMEM86B
TMEM97
TMPRSS4
TMUB2
TRAM1L1
TSPAN33
UNC50
UPK1B
VAMP3
VAMP4
VAMP5
VKORC1L1
VSTM1
VTI1B
YIF1A
YIPF6
ZDHHC22
11 interacting genes:
CLEC7A
CSNK1A1
CSNK2A1
FATE1
GPX8
PTPN2
SNW1
SYNE4
TJP1
TNFAIP3
ULK1
Entrez ID
493869
100506658
HPRD ID
17416
Ensembl ID
ENSG00000164294
ENSG00000197822
Uniprot IDs
B4DPY0
E7ETY7
J3KNB5
Q8TED1
A8K3T2
Q16625
PDB IDs
3CYN
3KIJ
1WPA
1XAW
3G7C
Enriched GO Terms of Interacting Partners
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