GPX8 and VAMP4

Data Source:
BioGRID (two hybrid)

		GPX8	VAMP4
Description		glutathione peroxidase 8 (putative)	vesicle associated membrane protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Integral Component Of Membrane	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Cell Surface Transport Vesicle Integral Component Of Synaptic Vesicle Membrane Clathrin-coated Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding	Protein Binding
	Biological Process	Cellular Response To Oxidative Stress Cellular Oxidant Detoxification	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Membrane Organization Golgi Ribbon Formation Regulation Of Synaptic Vesicle Endocytosis
Pathways		Detoxification of Reactive Oxygen Species	Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Glutathione Glutathione disulfide
Diseases
GWAS		Cocaine dependence ( 31212010)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		152 interacting genes: - AGTRAP AIG1 ALG8 APOC3 APOD AQP1 AQP2 AQP3 ASGR1 ASPH BCL2L2 BET1 BIK BMP10 BNIP2 BTN2A2 C14orf180 C1GALT1 CACNG1 CD302 CD53 CD81 CDIPT CDS2 CFHR5 CHST1 CLDN19 CLEC1A CLEC2A CMTM5 CNIH1 CNIH3 COL4A5 COL8A2 CORIN CYB561 CYB561A3 CYB561D2 DNAJC30 DOLK EDDM3B ERG28 ERO1A FA2H FAM3C FAXDC2 GET3 GOSR2 GPR151 GPR37L1 GRINA GYPA HHATL HMOX2 IGFBP5 INSIG2 KIR2DL3 KLRG1 LAPTM4B LEPROTL1 LHFPL5 LNPEP LPAR3 MAN2B2 MARCHF2 MARCHF5 MFSD5 MFSD6 MGST2 MGST3 MIP MMD MYADML2 NEU1 NINJ1 NIPAL3 NKG7 NRM OCLN PAEP PAQR5 PAQR6 PGAP2 PLLP PLN PLP2 PLPP4 PLPP6 PNLIPRP1 PRB1 RBFA RND1 RTP2 SCARB2 SCARF1 SCD SEC22B SELENOK SERINC1 SERINC2 SERP1 SERTM1 SFTPC SGMS2 SLC13A3 SLC30A3 SLC34A3 SLC35A1 SLC35B4 SLC41A2 SMAGP SNORC ST6GAL2 STX3 STX8 SYT15 TF THBD TIMMDC1 TM4SF4 TMBIM6 TMEM107 TMEM109 TMEM120B TMEM128 TMEM14B TMEM19 TMEM218 TMEM229B TMEM243 TMEM254 TMEM42 TMEM50B TMEM60 TMEM86B TMEM97 TMPRSS4 TMUB2 TRAM1L1 TSPAN33 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1L1 VSTM1 VTI1B YIF1A YIPF6 ZDHHC22	45 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SEC11C SLC10A6 SNAP29 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54
Entrez ID		493869	8674
HPRD ID		17416	06070
Ensembl ID		ENSG00000164294	ENSG00000117533
Uniprot IDs		B4DPY0 E7ETY7 J3KNB5 Q8TED1	O75379 Q6IAZ3
PDB IDs		3CYN 3KIJ
Enriched GO Terms of Interacting Partners?
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