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CCNB1 and KAT5
Data Source:
HPRD
(in vitro, in vivo)
CCNB1
KAT5
Description
cyclin B1
lysine acetyltransferase 5
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Cytosol
Membrane
Cyclin B1-CDK1 Complex
Swr1 Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Piccolo NuA4 Histone Acetyltransferase Complex
NuA4 Histone Acetyltransferase Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Transcription Coregulator Activity
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Acetyltransferase Activity
Histone Binding
Metal Ion Binding
Peptide-lysine-N-acetyltransferase Activity
Repressing Transcription Factor Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase II Promoter
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Spindle Organization
Mitotic Nuclear Envelope Disassembly
Mitotic Metaphase Plate Congression
Spermatogenesis
Response To Mechanical Stimulus
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of MRNA 3'-end Processing
Positive Regulation Of Histone Phosphorylation
Tissue Regeneration
Response To Drug
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Regulation Of Cell Cycle
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Organic Cyclic Compound
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Negative Regulation Of Transcription By RNA Polymerase II
DNA Double-strand Break Processing
DNA Replication
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Response To Ionizing Radiation
Positive Regulation Of Autophagy
Viral Process
Histone Acetylation
Protein Phosphopantetheinylation
Peptidyl-lysine Acetylation
Negative Regulation Of Interleukin-2 Production
Regulation Of Growth
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Acetylation
Beta-catenin-TCF Complex Assembly
Pathways
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerisation of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
DNA Damage/Telomere Stress Induced Senescence
HATs acetylate histones
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Estrogen-dependent gene expression
Drugs
Coenzyme A
S-Acetyl-Cysteine
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Chronic kidney disease (
20383146
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate (
31152163
)
HDL cholesterol (
24097068
)
HDL cholesterol levels (
32203549
28334899
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Triglyceride levels (
32203549
)
Triglycerides (
30275531
)
Interacting Genes
59 interacting genes:
ANAPC11
ARID4A
BRCA1
CCNB1IP1
CCNF
CDC20
CDC25A
CDC25C
CDC27
CDC34
CDC6
CDK1
CDKN1A
CDKN1B
CDT1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
MAP4
MEF2C
MOK
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
POLA1
PRC1
PRKDC
PRKN
PTCH1
PTMA
RALBP1
RB1
RPA1
RUNX2
SQSTM1
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2C
UBE2D2
UBE2N
UBE2S
UBE3C
UBE3D
XIAP
191 interacting genes:
AGO2
ALOX12
ALX1
ANTKMT
APBB1
APLP1
APLP2
APP
AR
ARIH2
ATF3
ATM
ATXN1
BACH2
BARD1
BCL3
BLZF1
BMI1
BRCA1
C1orf131
C1orf174
CAVIN1
CBX8
CCDC106
CCDC125
CCDC136
CCNB1
CCT7
CDC42
CDK1
CDK5RAP2
CDKN2A
CEP126
CEP70
CREB1
CREBBP
CRELD1
CSTF2
DLEU1
DNAAF6
DUSP23
E2F1
E2F4
EDNRA
EFNA1
EP300
EP400
EPC1
ESR1
ESR2
ETV6
FAM135B
FAM161A
FCHO1
GADD45G
GAPDH
GEMIN7
GET4
GIGYF1
GKAP1
GMCL1
GMCL2
GOLGA2
GSTO1
GTF2E2
H2AC20
H2AC4
H2AX
H3-3B
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
HABP4
HAP1
HDAC1
HDAC7
HMBOX1
HNRNPH3
HSF2BP
ID3
IFT20
IK
IKZF3
IL9R
KCTD7
KLF4
KPNA3
KPNA4
KPNA5
KPNA6
KRT40
KRTAP10-3
KRTAP10-9
LMNA
LONRF1
LRIF1
LRP1
LZTS1
LZTS2
MAD2L1BP
MAPRE1
MCC
MCPH1
MDFI
MDM2
MEOX2
MTUS2
MYC
MYOD1
NAP1L5
NDUFA4L2
NDUFV2
NFKB1
NINL
NR3C1
ODC1
OGFOD2
PDCD5
PFKP
PHC2
PICK1
PITX2
PLA2G4A
PLEKHA4
PML
POLE2
POLR3F
PPARG
PPP1R16A
PRDM6
PROSER2
PTPN4
PTPRS
RB1
RCHY1
RELA
RFLNB
RGL2
RRM2
SAT1
SCRN2
SERTAD2
SHISA6
SNAPIN
SNRPD2
SOX5
SPATA2
SQSTM1
SRF
SRSF2
SSX2IP
STAT3
STMN3
STX11
SYCE1
SYN1
TAX1BP1
TBX5
TELO2
TFIP11
TMCC2
TNNT1
TP53
TRIB3
TRIM23
TRIM27
TRIM29
TRIM37
TUFT1
UBASH3B
UHRF1
UPRT
USP7
YJU2
YWHAG
ZBTB1
ZBTB14
ZBTB2
ZBTB8A
ZC2HC1C
ZEB1
ZNF24
ZNF417
ZNF511
ZNF513
ZNF526
ZNF692
ZSCAN4
Entrez ID
891
10524
HPRD ID
00454
03245
Ensembl ID
ENSG00000134057
ENSG00000172977
Uniprot IDs
P14635
A0A024R597
A0A024R5E8
Q92993
PDB IDs
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
2EKO
2OU2
4QQG
Enriched GO Terms of Interacting Partners
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