UBE2V1 and ZNRF1

Data Source:
BioGRID (two hybrid)

		UBE2V1	ZNRF1
Description		ubiquitin conjugating enzyme E2 V1	zinc and ring finger 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome	Lysosome Endosome Cytosol Membrane Synaptic Vesicle Membrane
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Activation Of MAPK Activity Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated JNK Cascade Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination	Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Interacting Genes		47 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN PSMD14 RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1	15 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W UBXN7
Entrez ID		7335	84937
HPRD ID		04294	15893
Ensembl ID		ENSG00000244687	ENSG00000186187
Uniprot IDs		G3V2F7 Q13404	Q8ND25
PDB IDs		2A4D 2C2V 2HLW 6D6I	5YWR
Enriched GO Terms of Interacting Partners?
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