BAG6 and PLPP2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BAG6	PLPP2
Description		BAG cochaperone 6	phospholipid phosphatase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome BAT3 Complex	Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Integral Component Of Membrane Early Endosome Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Misfolded Protein Binding Proteasome Binding Ubiquitin-specific Protease Binding	Protein Binding Phosphatidate Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity
	Biological Process	Kidney Development Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Ubiquitin-dependent ERAD Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ER-associated Misfolded Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Maintenance Of Unfolded Protein Involved In ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway	Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Signal Transduction Sphingolipid Biosynthetic Process Phospholipid Dephosphorylation Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Height ( 28552196) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		118 interacting genes: ACVR1B AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CHN2 CILK1 CLU CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GET4 GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT IQCG KLHL12 KPNA2 LBP MAPK6 MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL4B UBL7 UBQLN1 UBQLN2 UBQLN4 USP13 VAMP2 XRN1 ZFYVE9	9 interacting genes: BAG6 HNF4A JAGN1 MRPL44 NOTCH2NLA NSG1 TRAM1L1 UNC119 VSTM1
Entrez ID		7917	8612
HPRD ID		00808	06180
Ensembl ID		ENSG00000204463	ENSG00000141934
Uniprot IDs		A0A1U9X7A6 P46379	O43688
PDB IDs		1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8
Enriched GO Terms of Interacting Partners?
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